1-Methyl-4,4-diphenylpiperidine

Base Information

• Chemical Name: 1-Methyl-4,4-diphenylpiperidine
• CAS No.: 31309-39-4
• Molecular Formula: C18H21 N
• Molecular Weight: 251.371
• DSSTox Substance ID: DTXSID401304641
• Wikidata: Q107855777
• Mol file: 31309-39-4.mol

Synonyms:1-methyl-4,4-diphenylpiperidine;4-diphenyl-N-methyl-piperidine;SCHEMBL11738164;4,4-Diphenyl-1-methylpiperidine;DTXSID401304641;E79731;31309-39-4

Chemical Property of 1-Methyl-4,4-diphenylpiperidine

Chemical Property:

• XLogP3: 4.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 251.167399674
• Heavy Atom Count: 19
• Complexity: 245

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCC(CC1)(C2=CC=CC=C2)C3=CC=CC=C3

Technology Process of 1-Methyl-4,4-diphenylpiperidine

There total 12 articles about 1-Methyl-4,4-diphenylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-Methyl-4-piperidone (1445-73-4) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → Medipine (31309-39-4)

Guidance literature:

With trifluorormethanesulfonic acid; at 20 ℃; for 3h;

DOI:10.1002/chem.200400835

Reference yield:

N,N-dimethyl-3,3-diphenylpropan-1-amine (4646-55-3) → Medipine (31309-39-4)

Guidance literature:

Multi-step reaction with 2 steps

1: KNH₂; liquid NH₃

2: 310 °C

With ammonia; potassium amide;

DOI:10.1021/ja01101a034

Reference yield:

1-methyl-4-phenyl-piperidin-4-ol (4972-68-3) + iron(III) chloride (7705-08-0) → Medipine (31309-39-4)

Guidance literature:

With sodium hydroxide; In benzene;

upstream raw materials:

1-Methyl-4-piperidone

benzene

acetic acid-(1-methyl-4-phenyl-[4]piperidyl ester)

3-benzoyl-4-hydroxy-1-methyl-4-phenylpiperidine

Refernces

• 1、 Schaefer,Hackmack,Eistetter,Krueger,Menge,Klosa. "Synthesis, physico-chemical properties and pharmacological screening results of budipine and related 1-alkyl-4,4-diphenylpiperidines". . p. 233 - 240. Retrieved 2007/10/02.
• 2、 -. "4,4-Diarylpiperidines and process of making the same". . . Retrieved 2008/06/13.