4-Methylcyclohexanoneoxime

Base Information

• Chemical Name: 4-Methylcyclohexanoneoxime
• CAS No.: 4994-13-2
• Molecular Formula: C₇H₁₃NO
• Molecular Weight: 127.186
• Mol file: 4994-13-2.mol

Synonyms:4-Methylcyclohexanone oxime;Cyclohexanone,4-methyl-,oxime;4-metylcyclohexanone oxime;(+-)-1-Methyl-cyclohexanon-(4)-oxim;(+-)-1-methyl-cyclohexanone-(4)-oxime;4-Methyl-cyclohexanon-oxim;N-hydroxy-4-methylcyclohexanimine;1-Methyl-cyclohexanoxim-(4);

Chemical Property of 4-Methylcyclohexanoneoxime

Chemical Property:

• Vapor Pressure: 0.0486mmHg at 25°C
• Boiling Point: 218.1°Cat760mmHg
• Flash Point: 117.5°C
• PSA: 32.59000
• Density: 1.08g/cm³
• LogP: 2.02670

Purity/Quality:

98.5% ^*data from raw suppliers

4-methylcyclohexanoneoxime ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Methylcyclohexanoneoxime

There total 4 articles about 4-Methylcyclohexanoneoxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-methylcyclohexan-4-one (589-92-4) → 4-methylcyclohexanone oxime (4994-13-2,128925-57-5,128925-58-6)

Guidance literature:

With hydroxylamine hydrochloride; sodium acetate; at 40 ℃; for 0.5h;

Reference yield:

4-methylcyclohexylamine (6321-23-9) → 4-methylcyclohexanone oxime (4994-13-2,128925-57-5,128925-58-6)

Guidance literature:

With tungsten trioxide; aluminum oxide; 2,2-diphenyl-1-(2,4,6-trinitrophenyl)hydrazyl; oxygen; In acetonitrile; at 80 ℃; for 8h; under 37503.8 Torr;

DOI:10.1002/anie.200705002

Reference yield:

methyl cyclohexane (82166-21-0) → 2-methylcyclohexanone oxime (1122-26-5) + 4-methylcyclohexanone oxime (4994-13-2,128925-57-5,128925-58-6) + 3-methyl-cyclohexanone oxime (4701-95-5)

Guidance literature:

With nitrosylchloride; Irradiation;

upstream raw materials:

methyl cyclohexane

1-methylcyclohexan-4-one

4-methylcyclohexylamine

Downstream raw materials:

2-acetoxy-4-methylcyclohexanone

2,6-dimethyl-4,5,6,7-tetrahydro benzoxazole

Acetic acid 2-diacetylamino-5-methyl-cyclohex-1-enyl ester

Acetic acid 2-diacetylamino-5-methyl-cyclohex-2-enyl ester

Refernces

• 1、 Suzuki, Ken,Watanabe, Tomonari,Murahashi, Shun-Ichi. "Aerobic oxidation of primary amines to oximes catalyzed by DPPH and WO 3/Al2O3". supporting information; experimental part. p. 2079 - 2081. Retrieved 2009/02/06.
• 2、 Pau,Cerri,Boatto,Palomba,Pintore,Filippelli,Falcone,Palagiano,Rossi. "Synthesis of amides with anti-inflammatory and analgesic activities". . p. 93 - 98. Retrieved 2007/10/03.