Aspartic Acid

Base Information

• Chemical Name: Aspartic Acid
• CAS No.: 25608-40-6
• Deprecated CAS: 181119-33-5,6899-03-2,2139279-07-3,181119-34-6,221628-95-1,26834-87-7,155436-59-2,155436-61-6,155436-63-8,155436-65-0,90819-17-3,1236300-18-7,1393950-57-6,1436923-03-3,2197132-19-5
• Molecular Formula: C₄H₇NO₄
• Molecular Weight: 133.104
• European Community (EC) Number: 200-291-6,614-886-7,642-993-9
• ICSC Number: 1439
• UNII: 30KYC7MIAI
• DSSTox Substance ID: DTXSID7022621
• Nikkaji Number: J9.169C
• Wikipedia: Aspartic acid
• Wikidata: Q178450
• NCI Thesaurus Code: C29608
• RXCUI: 1169
• Metabolomics Workbench ID: 37126
• ChEMBL ID: CHEMBL274323
• Mol file: 25608-40-6.mol

Synonyms:(+-)-Aspartic Acid;(R,S)-Aspartic Acid;Ammonium Aspartate;Aspartate;Aspartate Magnesium Hydrochloride;Aspartate, Ammonium;Aspartate, Calcium;Aspartate, Dipotassium;Aspartate, Disodium;Aspartate, Magnesium;Aspartate, Monopotassium;Aspartate, Monosodium;Aspartate, Potassium;Aspartate, Sodium;Aspartic Acid;Aspartic Acid, Ammonium Salt;Aspartic Acid, Calcium Salt;Aspartic Acid, Dipotassium Salt;Aspartic Acid, Disodium Salt;Aspartic Acid, Hydrobromide;Aspartic Acid, Hydrochloride;Aspartic Acid, Magnesium (1:1) Salt, Hydrochloride, Trihydrate;Aspartic Acid, Magnesium (2:1) Salt;Aspartic Acid, Magnesium-Potassium (2:1:2) Salt;Aspartic Acid, Monopotassium Salt;Aspartic Acid, Monosodium Salt;Aspartic Acid, Potassium Salt;Aspartic Acid, Sodium Salt;Calcium Aspartate;Dipotassium Aspartate;Disodium Aspartate;L Aspartate;L Aspartic Acid;L-Aspartate;L-Aspartic Acid;Magnesiocard;Magnesium Aspartate;Mg-5-Longoral;Monopotassium Aspartate;Monosodium Aspartate;Potassium Aspartate;Sodium Aspartate

Chemical Property of Aspartic Acid

Chemical Property:

• Melting Point: 140 °C (decomp)
• PSA: 100.62000
• LogP: -0.42670
• XLogP3: -2.8
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 133.03750770
• Heavy Atom Count: 9
• Complexity: 133

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Chemical Classes: Biological Agents -> Amino Acids and Derivatives
• Canonical SMILES: C(C(C(=O)O)N)C(=O)O
• Isomeric SMILES: C([C@@H](C(=O)O)N)C(=O)O
• Recent ClinicalTrials: Prevention and Treatment for COVID -19 (Severe Acute Respiratory Syndrome Coronavirus 2 SARS-CoV-2) Associated Severe Pneumonia in the Gambia
• Recent EU Clinical Trials: International phase 3 trial in Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) testing imatinib in combination with two different cytotoxic chemotherapy backbones
• Inhalation Risk: Evaporation at 20 °C is negligible; a nuisance-causing concentration of airborne particles can, however, be reached quickly when dispersed, especially if powdered.
• Effects of Short Term Exposure: The substance is irritating to the eyes and respiratory tract.
• Uses: antihemophilic factor

Technology Process of Aspartic Acid

There total 442 articles about Aspartic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-Asparagine (2058-58-4,28088-48-4,7006-34-0) → (2R)-aspartic acid (1783-96-6,25608-40-6,27881-03-4,32505-46-7,52526-39-3)

Guidance literature:

With hydrogenchloride;

Reference yield:

aspartic Acid (617-45-8,25608-40-6,27881-03-4,32505-46-7,52526-39-3) → (2R)-aspartic acid (1783-96-6,25608-40-6,27881-03-4,32505-46-7,52526-39-3)

Guidance literature:

durch Spaltung;

Reference yield:

bromosuccinic acid (923-06-8,584-98-5) → (2R)-aspartic acid (1783-96-6,25608-40-6,27881-03-4,32505-46-7,52526-39-3)

Guidance literature:

With ammonia; water; at -50 - -40 ℃; dann bei 3-5grad, endlich bei Zimmertemperatur;

upstream raw materials:

aniline

(+/-)-phthaloylaspartic acid

diazo-succinic acid diethyl ester

Oxalacetic acid

Downstream raw materials:

IAA-aspartate

L-aspartic acid diethyl ester

aspartic acid 4-ethyl ester

N-[(2,4,5-trichloro-phenoxy)-acetyl]-D-aspartic acid

Refernces

• 1、 Larsen et al.. "". . p. 842. Retrieved 1972.
• 2、 Christy, M. Robert,Koch, Tad H.. "Chemical Reactivity of the New Amino Acid β-Carboxyaspartic Acid (Asa)". . p. 1771 - 1772. Retrieved 1982.
• 3、 Harada,Nakamura. "-". . p. 9. Retrieved 1978.
• 4、 Maggi, Maristella,Chiarelli, Laurent R.,Valentini, Giovanna,Scotti, Claudia. "Engineering of helicobacter pylori lasparaginase: Characterization of two functionally distinct groups of mutants e0117025". . . Retrieved 2015.
• 5、 Jia, Mingmei,Xu, Meijuan,He, Beibei,Rao, Zhiming. "Cloning, expression, and characterization of L-asparaginase from a newly isolated Bacillus subtilis B11-06". . p. 9428 - 9434. Retrieved 2013.
• 6、 Liwschitz,Y.,Singerman,A.. "-". . p. 1200 - 1202. Retrieved 1966.
• 7、 Tran-Cong, Nam Michael,Mándi, Attila,Kurtán, Tibor,Müller, Werner E.G.,Kalscheuer, Rainer,Lin, Wenhan,Liu, Zhen,Proksch, Peter. "Induction of cryptic metabolites of the endophytic fungus: Trichocladium sp. through OSMAC and co-cultivation". . p. 27279 - 27288. Retrieved 2019.
• 8、 Zhang, Yangmei,Wang, Gang,Lv, Huawei,Luo, Jianguang,Kong, Lingyi. "Two new β-carboline alkaloids from the roots of Gypsophila oldhamiana". . p. 1207 - 1211. Retrieved 2015.
• 9、 Noma, Samir Abbas Ali,Ulu, Ahmet,Acet, ?mür,Sanz, Raúl,Sanz-Pérez, Eloy S.,Odaba?i, Mehmet,Ate?, Burhan. "Comparative study of ASNase immobilization on tannic acid-modified magnetic Fe3O4/SBA-15 nanoparticles to enhance stability and reusability". . p. 4440 - 4451. Retrieved 2020.
• 10、 Chen, Min,Chen, Rouwen,Ding, Wenping,Li, Yanqun,Tian, Xinpeng,Yin, Hao,Zhang, Si. "Structures and antitumor activities of ten new and twenty known surfactins from the deep-sea bacterium Limimaricola sp. SCSIO 53532". . . Retrieved 2022/01/11.