Dimethylethylamine hydrochloride

Base Information

• Chemical Name: Dimethylethylamine hydrochloride
• CAS No.: 58114-25-3
• Molecular Formula: C4H11N.ClH
• Molecular Weight: 109.599
• DSSTox Substance ID: DTXSID10502409
• Mol file: 58114-25-3.mol

Synonyms:dimethylethylamine hydrochloride;58114-25-3;N,N-dimethylethanamine;hydrochloride;N,N-Dimethylethylamine hydrochloride;SCHEMBL435643;DTXSID10502409;KSKTVNNRMXUMIY-UHFFFAOYSA-N

Chemical Property of Dimethylethylamine hydrochloride

Chemical Property:

• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 109.0658271
• Heavy Atom Count: 6
• Complexity: 17.6

Purity/Quality:

98%Min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCN(C)C.Cl

Technology Process of Dimethylethylamine hydrochloride

There total 4 articles about Dimethylethylamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N,N-dimethylacetamide dimethyl acetal (18871-66-4) → N,N-dimethylaminoethane hydrochloride (58114-25-3)

Guidance literature:

N,N-dimethylacetamide dimethyl acetal; With 5% palladium on Al₂O₃; hydrogen; In methanol; at 25 ℃; under 30003 Torr; Autoclave;

With hydrogenchloride; In methanol; water; Reagent/catalyst;

Reference yield: 96.0%

N,N-dimethyl acetamide (127-19-5,116057-81-9) → N,N-dimethylaminoethane hydrochloride (58114-25-3)

Guidance literature:

N,N-dimethyl acetamide; With [κ²-{Ph₂P(Se)NC₉H₆N}Al(Me)₂]; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; at 20 ℃; for 12h; Schlenk technique; Glovebox;

With hydrogenchloride; In water; chemoselective reaction;

DOI:10.1039/c9dt01806a

Reference yield:

N-(1-chloroethylidene)-N-methylmethanaminium chloride (58569-87-2) → N,N-dimethylaminoethane hydrochloride (58114-25-3)

Guidance literature:

With hydrogen; tris(2,6-difluorophenyl)borane triethylphosphine oxide; In chloroform; at 50 ℃; for 48h; under 60006 Torr; Autoclave;

DOI:10.1021/jacs.8b12997

upstream raw materials:

N,N-dimethyl-ethanamine

vinylsulfonyl chloride

N,N-dimethylacetamide dimethyl acetal

N,N-dimethyl acetamide

Downstream raw materials:

N,N,4-Trimethyl-5-[(2,3,6-trifluorophenyl)[(3,3,3-trifluoropropyl)sulfonyl]methyl]pyridine-2-carboxamide

3-[4-(2-Dimethylamino-ethoxy)-phenyl]-5-methyl-2,6-diphenyl-furo[3,2-g]chromen-7-one

Refernces

• 1、 Das, Suman,Karmakar, Himadri,Bhattacharjee, Jayeeta,Panda, Tarun K.. "Aluminium complex as an efficient catalyst for the chemo-selective reduction of amides to amines". . p. 11978 - 11984. Retrieved 2019/08/13.
• 2、 -. "Catalytic Hydrogenation for the Preparation of Amines from Amide Acetals, Ketene N,O-Acetals or Ester Imides". Paragraph 0150; 0152. . Retrieved 2016/10/04.