4-chloro-2-ethylBenzoic acid

Base Information

• Chemical Name: 4-chloro-2-ethylBenzoic acid
• CAS No.: 58231-16-6
• Molecular Formula: C9H9ClO2
• Molecular Weight: 184.622
• Mol file: 58231-16-6.mol

Synonyms:4-Chlor-2-cyclopropyl-but-3-in-2-ol;4-Chlor-2-ethyl-benzoesaeure;4-chloro-2-cyclopropyl-but-3-yn-2-ol;4-Chloro-2-cyclopropyl-3-butyn-2-ol;3-Butyn-2-ol,4-chloro-2-cyclopropyl;

Chemical Property of 4-chloro-2-ethylBenzoic acid

Chemical Property:

• PSA: 37.30000
• LogP: 2.60060

Purity/Quality:

95% ^*data from raw suppliers

4-Chloro-2-ethylbenzoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-chloro-2-ethylBenzoic acid

There total 10 articles about 4-chloro-2-ethylBenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

4-chloro-2-methylbenzoic acid (7499-07-2) + methyl iodide (74-88-4) → 4-chloro-2-ethylbenzoic acid (58231-16-6)

Guidance literature:

4-chloro-2-methylbenzoic acid; With 2,2,6,6-tetramethylpiperidinyl-lithium; In tetrahydrofuran; hexane; at -50 ℃; for 1h;

methyl iodide; In tetrahydrofuran; hexane; at -50 - 20 ℃;

DOI:10.1021/jo0483365

Reference yield:

4-Ethyl-4-trichlormethyl-cyclohexa-2,5-dien-1-on (7504-39-4) → 4-chloro-2-ethylbenzoic acid (58231-16-6) + para-chlorobenzoic acid (74-11-3)

Guidance literature:

With phosphorus pentachloride;

DOI:10.1039/j39680000499

Reference yield:

para-chlorobenzoic acid (74-11-3) + methyl iodide (74-88-4) → 4-chloro-3-methylbenzoic acid (7697-29-2) + 4-chloro-2-methylbenzoic acid (7499-07-2) + 4-chloro-2-ethylbenzoic acid (58231-16-6)

Guidance literature:

para-chlorobenzoic acid; With 2,2,6,6-tetramethylpiperidinyl-lithium; In tetrahydrofuran; hexane; at -78 ℃; for 4h;

methyl iodide; In tetrahydrofuran; hexane; at -78 - 20 ℃;

DOI:10.1021/jo0483365

upstream raw materials:

2-Ethyl-4-chlor-benzonitril

4-Ethyl-4-trichlormethyl-cyclohexa-2,5-dien-1-on

4-chloro-2-methylbenzoic acid

methyl iodide

Downstream raw materials:

4-chlorophthalic acid

4-Chloro-5-chlorosulfonyl-2-ethyl-benzoic acid

2-ethyl-4-chlorobenzoic acid chloride

N-t-butyl-α-(2-carboxy-5-chlorophenyl)-propionic acid amide

Refernces

• 1、 -. "HISTONE DEMETHYLASE INHIBITORS". Paragraph 00909 00910. . Retrieved 2014/06/24.
• 2、 Baumgarth, Manfred,Beier, Norbert,Gericke, Rolf. "(2-methyl-5-(methylsulfonyl)benzoyl)guanidine Na+/H+ antiporter inhibitors". . p. 2017 - 2034. Retrieved 2007/10/03.