4-(3-AMINO-PHENYL)-THIAZOL-2-YLAMINE

Base Information

• Chemical Name: 4-(3-AMINO-PHENYL)-THIAZOL-2-YLAMINE
• CAS No.: 103740-34-7
• Molecular Formula: C9H9N3S
• Molecular Weight: 191.257
• Hs Code.: 2934100090
• Mol file: 103740-34-7.mol

Synonyms:Thiazole,2-amino-4-(m-aminophenyl)- (6CI);NSC 38926;[4-(3-Aminophenyl)thiazol-2-yl]amine;

Chemical Property of 4-(3-AMINO-PHENYL)-THIAZOL-2-YLAMINE

Chemical Property:

• Vapor Pressure: 1.42E-08mmHg at 25°C
• Refractive Index: 1.715
• Boiling Point: 458 °C at 760 mmHg
• Flash Point: 230.8 °C
• PSA: 93.17000
• Density: 1.347 g/cm³
• LogP: 3.13690
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

4-(3-Amino-phenyl)-thiazol-2-ylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-(3-Amino-phenyl)-thiazol-2-ylamine is used as a reactant in the synthesis of novel 2-aminothiazole conjugated nitrofuran as antitubercular and antibacterial agents.

Technology Process of 4-(3-AMINO-PHENYL)-THIAZOL-2-YLAMINE

There total 12 articles about 4-(3-AMINO-PHENYL)-THIAZOL-2-YLAMINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

C11H11N3OS → 4-(3-aminophenyl)thiazole-2-amine (103740-34-7)

Guidance literature:

With hydrogenchloride; water; Reflux;

DOI:10.1016/j.bmcl.2016.05.088

Reference yield: 89.0%

1-(3-aminophenyl)ethanone (99-03-6) + thiourea (17356-08-0) → 4-(3-aminophenyl)thiazole-2-amine (103740-34-7)

Guidance literature:

With iodine; In ethanol; for 14h; Heating;

Reference yield: 85.6%

4-(3-nitrophenyl)thiazol-2-ylamine (57493-24-0) → 4-(3-aminophenyl)thiazole-2-amine (103740-34-7)

Guidance literature:

With iron; ammonium chloride; In ethanol; water; at 80 ℃; for 3h;

upstream raw materials:

1-(3-aminophenyl)ethanone

thiourea

3'-nitro-2-bromoacetophenone

3-Acetamidoacetophenone

Refernces

• 1、 Nizamuddin,Ahad, Hindustan Abdul,Devanna, Nayakanti. "Synthesis and Molecular Docking Studies of Some 1,2-Dimethyl-3(4-substituted phenyl-1,3-thiazol-2-yl)2,3-dihydroquinazolin-4(1H)-ones as Anticancer Agents". . p. 571 - 579. Retrieved 2021/02/02.
• 2、 -. "4-Phenylthiazole-2-amine derivative containing urea structure, and preparation method and application thereof". . . Retrieved 2019/03/28.