4-Phenyl-1-piperazineacetic acid ((3-hydroxy-4-methoxyphenyl)methylene)hydrazide

Base Information

• Chemical Name: 4-Phenyl-1-piperazineacetic acid ((3-hydroxy-4-methoxyphenyl)methylene)hydrazide
• CAS No.: 67041-04-7
• Molecular Formula: C₂₀H₂₄N₄O₃
• Molecular Weight: 368.436
• Mol file: 67041-04-7.mol

Synonyms:BRN 0855356;4-Phenyl-1-piperazineacetic acid ((3-hydroxy-4-methoxyphenyl)methylene)hydrazide;1-Piperazineacetic acid, 4-phenyl-, ((3-hydroxy-4-methoxyphenyl)methylene)hydrazide;67041-04-7;LS-110128

Chemical Property of 4-Phenyl-1-piperazineacetic acid ((3-hydroxy-4-methoxyphenyl)methylene)hydrazide

Chemical Property:

• XLogP3: 2.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 6
• Exact Mass: 368.18484064
• Heavy Atom Count: 27
• Complexity: 488

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)C=NNC(=O)CN2CCN(CC2)C3=CC=CC=C3)O
• Isomeric SMILES: COC1=C(C=C(C=C1)/C=N/NC(=O)CN2CCN(CC2)C3=CC=CC=C3)O

Technology Process of 4-Phenyl-1-piperazineacetic acid ((3-hydroxy-4-methoxyphenyl)methylene)hydrazide

There total 2 articles about 4-Phenyl-1-piperazineacetic acid ((3-hydroxy-4-methoxyphenyl)methylene)hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

isovanillin (621-59-0) + 4-phenyl-1-piperazineacetic acid hydrazide (1689-05-0) → 4-phenyl-1-piperazineacetic acid (3-hydroxy-4-methoxybenzylidene)hydrazide (67041-04-7)

Guidance literature:

With acetic acid; In ethanol; for 5h; Heating;

Reference yield:

→ 4-phenyl-1-piperazineacetic acid (3-hydroxy-4-methoxybenzylidene)hydrazide (67041-04-7)

Guidance literature:

4-Phenyl-piperazin-1-yl-essigsaeure-hydrazid (2a), 3-Hydroxy-4-methoxy-benzaldehyd;

Reference yield: 72.0%

4-phenyl-1-piperazineacetic acid (3-hydroxy-4-methoxybenzylidene)hydrazide (67041-04-7) → 2-Methoxy-5-[5-(4-phenyl-piperazin-1-ylmethyl)-[1,3,4]oxadiazol-2-yl]-phenol (127718-47-2)

Guidance literature:

With iron(III) chloride; In water; acetic acid; 1.) 1 h, 2.) RT, 2 d;

upstream raw materials:

isovanillin

4-phenyl-1-piperazineacetic acid hydrazide

Downstream raw materials:

2-Methoxy-5-[5-(4-phenyl-piperazin-1-ylmethyl)-[1,3,4]oxadiazol-2-yl]-phenol

Refernces

• 1、 Sengupta,Agarwal. "Search for potential psychotropic agents. II. N-benzylidene derivatives of 4-arylpiperazine-1-acetic acid hydrazides". . p. 89 - 94,91,92. Retrieved 2007/10/04.