DL-2-METHYLBUTYRYL CHLORIDE

Base Information

• Chemical Name: DL-2-METHYLBUTYRYL CHLORIDE
• CAS No.: 5856-79-1
• Molecular Formula: C₅H₉ClO
• Molecular Weight: 120.579
• Mol file: 5856-79-1.mol

Synonyms:2-METHYLBUTYROYL CHLORIDE;chlorure de l'acide (D,L)-2-methylbutyrique;2-methyl-butyric acid chloride;2-methylbutanoyl chloride;2-ethylpropanoyl chloride;2-methyl butyryl chloride;

Chemical Property of DL-2-METHYLBUTYRYL CHLORIDE

Chemical Property:

• Refractive Index: n20/D 1.418(lit.)
• Boiling Point: 117-121oC(lit.)
• Flash Point: 68 °F
• PSA: 17.07000
• Density: 0.972 g/mL at 25oC(lit.)
• LogP: 1.79790

Purity/Quality:

98%min ^*data from raw suppliers

2-Methylbutyryl chloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F,C
• Hazard Codes: F,C
• Statements: 11-34
• Safety Statements: 16-26-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of DL-2-METHYLBUTYRYL CHLORIDE

There total 10 articles about DL-2-METHYLBUTYRYL CHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2-Methylbutanoic acid (116-53-0,600-07-7) → iso-butyl chloroformate (5856-79-1,57526-28-0)

Guidance literature:

With thionyl chloride; N,N-dimethyl-formamide; at 40 ℃; for 2h;

DOI:10.1002/ejoc.200700015

Reference yield:

2-Methylbutanoic acid (116-53-0,600-07-7) + thionyl chloride (7719-09-7) → iso-butyl chloroformate (5856-79-1,57526-28-0)

Guidance literature:

In dichloromethane; at 25 ℃; for 12h;

DOI:10.1021/jm901229s

Reference yield:

2-Methyl-N-pyridin-3-yl-butyramide (119520-53-5) → iso-butyl chloroformate (5856-79-1,57526-28-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) hexamethyldisilazane, 1.6 M n-BuLi, 2.) CS₂, 3.) PhSeO₂H / 1.) THF, hexane, -20 deg C, 30 min, 2.) THF, rt, 3.) THF, rt, 5 h

2: oxalyl chloride, DMF / benzene / Ambient temperature

With carbon disulfide; n-butyllithium; oxalyl dichloride; benzeneseleninic acid; N,N-dimethyl-formamide; 1,1,1,3,3,3-hexamethyl-disilazane; In benzene;

DOI:10.1016/S0040-4020(01)85980-9

upstream raw materials:

2-Methylbutanoic acid

benzoyl chloride

1.1.3-Trichlor-butadien-(1.3)-carbonsaeure-⁽²⁾

Tiglic acid

Downstream raw materials:

2-methyl-1-(2,4,6-trihydroxyphenyl)-1-butanone

butyryl-(2-methyl-butyryl)-amine

2-ethyl-2-methylmalonic acid

3β,12α-bis-((Ξ)-2-methyl-butyryloxy)-solanid-5-ene

Refernces

• 1、 Yang, Jinyue,Fu, Xiaopan,Tang, Shibiao,Deng, Kezuan,Zhang, Lili,Yang, Xianjin,Ji, Yafei. "2-Amino-5,6-difluorophenyl-1 H-pyrazole-Directed PdII Catalysis: Arylation of Unactivated β-C(sp3)-H Bonds". . p. 10221 - 10236. Retrieved 2019/08/20.
• 2、 Chen, Gang,Shigenari, Toshihiko,Jain, Pankaj,Zhang, Zhipeng,Jin, Zhong,He, Jian,Li, Suhua,Mapelli, Claudio,Miller, Michael M.,Poss, Michael A.,Scola, Paul M.,Yeung, Kap-Sun,Yu, Jin-Quan. "Ligand-enabled β-C-H arylation of α-amino acids using a simple and practical auxiliary". supporting information. p. 3338 - 3351. Retrieved 2015/03/30.