Formamide, N-(2-acetylphenyl)-N-methyl-

Base Information

• Chemical Name: Formamide, N-(2-acetylphenyl)-N-methyl-
• CAS No.: 59019-35-1
• Molecular Formula: C10H11NO2
• Molecular Weight: 177.203
• DSSTox Substance ID: DTXSID80482885
• Wikidata: Q82319731
• Mol file: 59019-35-1.mol

Synonyms:Formamide, N-(2-acetylphenyl)-N-methyl-;59019-35-1;2'-acetyl-N-methylformanilide;SCHEMBL9796279;DTXSID80482885;GXHAWMSZNTWXKA-UHFFFAOYSA-N

Chemical Property of Formamide, N-(2-acetylphenyl)-N-methyl-

Chemical Property:

• PSA: 37.38000
• LogP: 2.11770
• XLogP3: 1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 177.078978594
• Heavy Atom Count: 13
• Complexity: 203

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)C1=CC=CC=C1N(C)C=O

Technology Process of Formamide, N-(2-acetylphenyl)-N-methyl-

There total 8 articles about Formamide, N-(2-acetylphenyl)-N-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

1,3-dimethylindole (875-30-9) → N-(2-acetylphenyl)-N-methylformamide (59019-35-1)

Guidance literature:

With tris(bipyridine)ruthenium(II) dichloride hexahydrate; potassium phosphate tribasic trihydrate; water; oxygen; In acetonitrile; at 20 ℃; Irradiation;

DOI:10.1002/ejoc.201701245

Reference yield: 70.0%

1,3-dimethylindole (875-30-9) → N-(2-acetylphenyl)-N-methylformamide (59019-35-1) + C14H20N2O2Si

Guidance literature:

With trimethylsilyl cyanide; oxygen; rose bengal; In acetonitrile; at -30 ℃; Irradiation;

DOI:10.1021/ja00304a045

Reference yield: 17.0%

1,3-dimethylindole (875-30-9) + trimethylsilyl cyanide (7677-24-9) → N-(2-acetylphenyl)-N-methylformamide (59019-35-1) + C14H20N2O2Si

Guidance literature:

With oxygen; rose bengal; In acetonitrile; at -30 ℃; Irradiation;

DOI:10.1021/ja00304a045

upstream raw materials:

1,3-dimethylindole

trimethylsilyl cyanide

acetaldehyde

2-(1-methyl-1H-indol-3-yl)acetic acid

Downstream raw materials:

1-methyl-4-quinolone

Refernces

• 1、 Ji, Xiaochen,Li, Dongdong,Wang, Zhongzhen,Tan, Muyun,Huang, Huawen,Deng, Guo-Jun. "Aerobic C–C Bond Cleavage of Indoles by Visible-Light Photoredox Catalysis with Ru(bpy)32+". . p. 6652 - 6659. Retrieved 2017/12/15.
• 2、 Amat-Guerri, Francisco,Lopez-Gonzalez, M. Mar C.,Martinez-Utrilla, Roberto. "DYE-SENSITIZED PHOTOOXIDATION OF 1-METHYLINDOLYL-3-ACETIC ACID". . p. 3749 - 3752. Retrieved 2007/10/02.