Methyl 6-bromo-2,3-dimethoxybenzoate

Base Information

• Chemical Name: Methyl 6-bromo-2,3-dimethoxybenzoate
• CAS No.: 59084-77-4
• Molecular Formula: C10H11BrO4
• Molecular Weight: 275.099
• DSSTox Substance ID: DTXSID90458834
• Nikkaji Number: J3.390.739G
• Wikidata: Q82282376
• Mol file: 59084-77-4.mol

Synonyms:Methyl 6-bromo-2,3-dimethoxybenzoate;59084-77-4;Methyl6-bromo-2,3-dimethoxybenzoate;DTXSID90458834

Chemical Property of Methyl 6-bromo-2,3-dimethoxybenzoate

Chemical Property:

• Storage Temp.: 2-8°C
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 273.98407
• Heavy Atom Count: 15
• Complexity: 222

Purity/Quality:

98%Min ^*data from raw suppliers

Methyl6-bromo-2,3-dimethoxybenzoate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C(=C(C=C1)Br)C(=O)OC)OC

Technology Process of Methyl 6-bromo-2,3-dimethoxybenzoate

There total 3 articles about Methyl 6-bromo-2,3-dimethoxybenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

6-bromo-2,3-dimethoxybenzaldehyde (53811-50-0) + dimethyl sulfate (77-78-1) → methyl 6-bromo-2,3-dimethoxybenzoate (59084-77-4)

Guidance literature:

6-bromo-2,3-dimethoxybenzaldehyde; With silver nitrate; sodium hydroxide; In water; acetonitrile; at 20 ℃; for 23h;

dimethyl sulfate; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield: 80.0%

6-bromo-2,3-dimethoxybenzoic acid (60555-93-3) + methyl iodide (74-88-4) → methyl 6-bromo-2,3-dimethoxybenzoate (59084-77-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

DOI:10.1021/jo061905j

Reference yield:

→ methyl 6-bromo-2,3-dimethoxybenzoate (59084-77-4)

Guidance literature:

aus d. entspr. Saeure (13) u. Diazomethan;

upstream raw materials:

6-bromo-2,3-dimethoxybenzoic acid

methyl iodide

6-bromo-2,3-dimethoxybenzaldehyde

dimethyl sulfate

Downstream raw materials:

Methyl-6-cyano-2,3-dimethoxybenzoat

6,7-dimethoxy-N-[(((1S,2R)-2-(1-methyl-1-phenylethyl)cyclohexyl)oxy)carbonyl]-2,3-dihydroisoindol-1-one

(3S)-4,5-dimethoxy-1-[6-(2-methoxyethyl)benzo[1,3]dioxol-5-ylmethyl]-3-oxo-1,3-dihydroisoindole-2-carboxylic acid (1S,2R)-2-(1-methyl-1-phenylethyl)cyclohexyl ester

methyl 6-[3-(1-hydroxy-6,7-methylenedioxynaphthyl)]-2,3-dimethoxybenzoate

Refernces

• 1、 -. "Method for synthesizing 6-6 fused ring structure in berberine and ebony natural product". Paragraph 0046; 0047; 0048. . Retrieved 2016/11/17.