NSC 407340

Base Information

• Chemical Name: NSC 407340
• CAS No.: 2066-88-8
• Molecular Formula: C7H9NO3
• Molecular Weight: 155.153
• Hs Code.: 2914400090
• Mol file: 2066-88-8.mol

Synonyms:3-(Formylmethyl)glutarimide;4-(2-Oxoethyl)-2,6-piperidinedione;(2,6-dioxo-[4]piperidyl)-acetaldehyde;(2,6-Dioxo-[4]piperidyl)-acetaldehyd;glutarimide acetaldehyde;2,6-Dioxo-4-piperidineacetaldehyde;4-(2-0xoethyl)-2,6-piperidinedione;2-(2,6-dioxo-4-piperidyl)acetaldehyde;(2,6-dioxo-piperidin-4-yl)-acetaldehyde;

Chemical Property of NSC 407340

Chemical Property:

• Vapor Pressure: 1.2E-05mmHg at 25°C
• Melting Point: 122-123 °C(Solv: acetone (67-64-1); hexane (110-54-3))
• Boiling Point: 369.3°Cat760mmHg
• PKA: 11.42±0.40(Predicted)
• Flash Point: 181.2°C
• PSA: 63.24000
• Density: 1.19g/cm³
• LogP: -0.04300

Purity/Quality:

99%min ^*data from raw suppliers

3-(Formylmethyl)glutarimide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-(Formylmethyl)glutarimide is a glutaramide derivative used in the preparation of antiviral agents.

Technology Process of NSC 407340

There total 5 articles about NSC 407340 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

3-[(dodecylthio-carbonyl)-methyl]-glutarimide (1149347-46-5) → (2,6-dioxo-piperidin-4-yl)-acetaldehyde (2066-88-8)

Guidance literature:

With triethylsilane; palladium 10% on activated carbon; at 20 ℃; for 1h;

DOI:10.1002/chem.201502861

Reference yield: 64.0%

(2,6-dioxo-piperidin-4-yl)-acetyl chloride (772-50-9) → (2,6-dioxo-piperidin-4-yl)-acetaldehyde (2066-88-8)

Guidance literature:

With 10% Pd-BaSO4; hydrogen; In toluene; for 3h; under 760.051 Torr; Reflux;

DOI:10.1248/cpb.58.1436

Reference yield: 60.0%

C17H15NO3S → (2,6-dioxo-piperidin-4-yl)-acetaldehyde (2066-88-8)

Guidance literature:

With triethylsilane; 5%-palladium/activated carbon; In tetrahydrofuran; for 7h; Inert atmosphere;

DOI:10.1002/chem.201300393

upstream raw materials:

(2,6-dioxo-piperidin-4-yl)-acetyl chloride

3-[(dodecylthio-carbonyl)-methyl]-glutarimide

(2,6-dioxopiperidin-4-yl)acetic acid

Downstream raw materials:

4-(2-hydroxy-4-oxo-5-o-tolylhexyl)piperidin-2,6-dione

4-(2-hydroxy-4-oxo-5-o-tolylpentyl)piperidin-2,6-dione

4-[4-(2,6-dioxo-piperidin-4-ylmethyl)-2-hydroxy-6-(4-nitro-phenyl)-3,4-dihydro-2H-pyran-3-yl]-piperidine-2,6-dione

Refernces

• 1、 Phillips et al.. "-". . p. 3517. Retrieved 1957.
• 2、 Micoine, Kévin,Persich, Peter,Llaveria, Josep,Lam, My-Hanh,Maderna, Andreas,Loganzo, Frank,Fürstner, Alois. "Total syntheses and biological reassessment of lactimidomycin, isomigrastatin and congener glutarimide antibiotics". . p. 7370 - 7383. Retrieved 2013/07/25.
• 3、 Ishikawa, Yuichi,Tachibana, Miyuki,Matsui, Chino,Obata, Rika,Umezawa, Kazuo,Nishiyama, Shigeru. "Synthesis and biological evaluation on novel analogs of 9-methylstreptimidone, an inhibitor of NF-κB". scheme or table. p. 1726 - 1728. Retrieved 2009/11/30.