N-(tert-Butoxycarbonyl)glycylglycine

Base Information

• Chemical Name: N-(tert-Butoxycarbonyl)glycylglycine
• CAS No.: 31972-52-8
• Molecular Formula: C9H16N2O5
• Molecular Weight: 232.236
• Hs Code.: 2924199090
• Mol file: 31972-52-8.mol

Synonyms:Glycine,N-(N-carboxyglycyl)-, N-tert-butyl ester (7CI,8CI);Glycine,N-[N-[(1,1-dimethylethoxy)carbonyl]glycyl]-;N-(N-Boc-glycyl)glycine;NSC 334375;[[2-(tert-Butoxycarbonylamino)acetyl]amino]acetic acid;tert-Butoxycarbonylglycylglycine;

Chemical Property of N-(tert-Butoxycarbonyl)glycylglycine

Chemical Property:

• Vapor Pressure: 7.32E-11mmHg at 25°C
• Melting Point: 132 °C
• Refractive Index: 1.483
• Boiling Point: 488.068 °C at 760 mmHg
• PKA: 3.41±0.10(Predicted)
• Flash Point: 248.975 °C
• PSA: 104.73000
• Density: 1.222 g/cm³
• LogP: 0.49370
• Storage Temp.: -15°C
• Solubility.: soluble in Methanol

Purity/Quality:

99.0% ^*data from raw suppliers

N-(tert-Butoxycarbonyl)glycylglycine ^*data from reagent suppliers

Safty Information:

• Statements: 43
• Safety Statements: 24/25-36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(tert-Butoxycarbonyl)glycylglycine

There total 18 articles about N-(tert-Butoxycarbonyl)glycylglycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

N-tert-butoxycarbonyl glycyl glycine methyl ester (53487-98-2) → Boc-Gly-Gly-OH (31972-52-8)

Guidance literature:

With lithium hydroxide monohydrate; In tetrahydrofuran; water; at 20 ℃; for 3h;

DOI:10.1021/acs.orglett.0c02403

Reference yield: 98.0%

N-(tert-butoxycarbonyl)glycylglycine benzyl ester (31972-51-7) → Boc-Gly-Gly-OH (31972-52-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 25 ℃; for 1h; under 2068.65 Torr;

DOI:10.1016/j.bmcl.2008.09.013

Reference yield: 96.0%

glycylglycine (556-50-3) + di-tert-butyl dicarbonate (24424-99-5) → Boc-Gly-Gly-OH (31972-52-8)

Guidance literature:

With guanidine hydrochloride; In ethanol; at 35 - 40 ℃; for 9h;

DOI:10.1016/j.tetlet.2011.01.023

upstream raw materials:

glycylglycine

tert-butyl cyanoformate

N-tert-butoxycarbonylglycylglycine ethyl ester

Boc-Gly-Gly-OPac

Downstream raw materials:

2-({2-[2-(2-tert-butoxycarbonylaminoacetylamino)acetylamino]acetyl}trimethylsilylmethylamino)-3-phenylpropionic acid methyl ester

Boc-Gly-Gly-Tyr-OH

N-tert-butoxycarbonylglycyl-glycyl-L-tyrosyl-L-prolyl-L-leucyl-L-isoleucyl-L-leucine methyl ester

Boc-Gly-Gly-Tyr-Pro-Leu-Ile-Leu-OPNP

Refernces

• 1、 Castillo Gomez, Juan Daniel,Hagenbach, Adelheid,Abram, Ulrich. "Propargyl-Substituted Thiocarbamoylbenzamidines of Technetium and Rhenium: Steps towards Bioconjugation with Use of Click Chemistry". . p. 5427 - 5434. Retrieved 2016.
• 2、 Parker,Oh,Moazami,Pierce,Loziuk,Dean,Muddiman. "Examining ubiquitinated peptide enrichment efficiency through an epitope labeled protein". . p. 114 - 119. Retrieved 2016.
• 3、 Kim, Ka Young,Kim, Jaehyeong,Park, Hyesong,Choi, Yeonweon,Kwon, Ki-Young,Jung, Jong Hwa. "Helical Inversion of Peptide-based Supramolecular Co2+ Complexes". . p. 988 - 994. Retrieved 2018.
• 4、 Guo, Peng,Wang, Ke,Jin, Wen-Jie,Xie, Hao,Qi, Liangliang,Liu, Xue-Yuan,Shu, Xing-Zhong. "Dynamic Kinetic Cross-Electrophile Arylation of Benzyl Alcohols by Nickel Catalysis". supporting information. p. 513 - 523. Retrieved 2021/01/12.
• 5、 Liu, Qihong,Wang, Hao,Li, Guotao,Liu, Miaochang,Ding, Jinchang,Huang, Xiaobo,Gao, Wenxia,Huayue, Wu. "A photocleavable low molecular weight hydrogel for light-triggered drug delivery". supporting information. p. 485 - 488. Retrieved 2018/06/19.