Technology Process of 3-(Ethoxycarbonyl)-4-methyl-1h-pyrrole-2-carboxylic acid
There total 9 articles about 3-(Ethoxycarbonyl)-4-methyl-1h-pyrrole-2-carboxylic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
2: 63 percent / dicyclohexylcarbodiimide / tetrahydrofuran / 18 h / 20 °C
3: 60 percent / H2 / 10percent Pd/C / ethanol / 3 h / 2585.7 Torr
4: 97 percent / I2, NaHCO3 / ethanol; H2O / 1.5 h / 20 °C
5: 93 percent / H2, sodium acetate / 10percent Pd/C / ethanol / 3 h / 2327.2 Torr
6: 80 percent / trifluoroacetic acid / 0.25 h / 5 °C
With
hydrogen; iodine; sodium acetate; sodium hydrogencarbonate; dicyclohexyl-carbodiimide; trifluoroacetic acid;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; water;
DOI:10.1021/jo00137a006
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 1.) NaNO2, acetic acid, 2.) Zn, acetic acid, sodium acetate / 1.) H2O, 5 deg C, 15 h, 2.) 75 deg C, 1.5 h
3: 63 percent / dicyclohexylcarbodiimide / tetrahydrofuran / 18 h / 20 °C
4: 60 percent / H2 / 10percent Pd/C / ethanol / 3 h / 2585.7 Torr
5: 97 percent / I2, NaHCO3 / ethanol; H2O / 1.5 h / 20 °C
6: 93 percent / H2, sodium acetate / 10percent Pd/C / ethanol / 3 h / 2327.2 Torr
7: 80 percent / trifluoroacetic acid / 0.25 h / 5 °C
With
hydrogen; iodine; sodium acetate; sodium hydrogencarbonate; acetic acid; dicyclohexyl-carbodiimide; trifluoroacetic acid; zinc; sodium nitrite;
palladium on activated charcoal;
In
tetrahydrofuran; ethanol; water;
DOI:10.1021/jo00137a006