Technology Process of Methyl 2,3,6-trimethoxybenzoate
There total 5 articles about Methyl 2,3,6-trimethoxybenzoate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1,2,4-trimethoxy-benzene;
With
n-butyllithium;
In
tetrahydrofuran;
at -10 - 25 ℃;
for 2.16667h;
Inert atmosphere;
methyl chloroformate;
In
ethanol;
at -10 - 20 ℃;
for 16h;
Inert atmosphere;
- Guidance literature:
-
With
lithium hydroxide;
In
tetrahydrofuran;
for 6h;
Heating;
DOI:10.1021/jo051082i
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: n-butyllithium / diethyl ether; hexane / 3.5 h / 0 - 20 °C
1.2: 75 percent / diethyl ether; hexane / -60 - 20 °C
2.1: 94 percent / lithium hydroxide monohydrate / tetrahydrofuran / 6 h / Heating
With
lithium hydroxide; n-butyllithium;
In
tetrahydrofuran; diethyl ether; hexane;
DOI:10.1021/jo051082i