H-Aib-OBzl

Base Information

• Chemical Name: H-Aib-OBzl
• CAS No.: 60421-20-7
• Molecular Formula: C11H15NO2.ClH
• Molecular Weight: 229.707
• Mol file: 60421-20-7.mol

Synonyms:H-Aib-OBn*HCl;2-Methylalanine benzyl ester hydrochloride;benzyl-2-amino-2-methylpropanoate hydrochloride salt;Benzyl |A-aminoisobutyrate hydrochloride;benzyl 2-amino-2-methylpropanoate hydrochloride;2-aminoisobutyrate benzyl ester hydrochloride;benzyl 2-aminoisobutyryl hydrochloride;H-Aib-OBzl;Benzyl 2-amino-2-methylpropionate hydrochloride;2-amino-2-methyl-propionic acid benzyl ester hydrochloride;

Chemical Property of H-Aib-OBzl

Chemical Property:

• Melting Point: 170-171℃
• PSA: 52.32000
• LogP: 2.96940
• Storage Temp.: 2-8°C
• Solubility.: H2O: soluble50mg/mL, clear, colorless

Purity/Quality:

99.3% ^*data from raw suppliers

Benzyl α-aminoisobutyrate hydrochloride ≥98% (HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of H-Aib-OBzl

There total 5 articles about H-Aib-OBzl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.4%

→ benzyl 2-amino-2-methylpropionate hydrochloride (60421-20-7)

Guidance literature:

Reference yield: 60.0%

benzyl 2-aminoisobutyrate (55456-40-1) → benzyl 2-amino-2-methylpropionate hydrochloride (60421-20-7)

Guidance literature:

With hydrogenchloride; In diethyl ether; at 0 ℃; for 16h;

Reference yield: 59.0%

2-Aminoisobutyric acid (62-57-7) + benzyl alcohol (100-51-6,185532-71-2) → benzyl 2-amino-2-methylpropionate hydrochloride (60421-20-7)

Guidance literature:

2-Aminoisobutyric acid; benzyl alcohol; With toluene-4-sulfonic acid; In toluene; for 6 - 24h; Heating / reflux;

With potassium carbonate; In dichloromethane; water;

With hydrogenchloride; In water; acetone;

upstream raw materials:

tert-butoxycarbonylamino-2-methyl-propionic acid benzyl ester

benzyl 2-aminoisobutyrate

2-Aminoisobutyric acid

benzyl alcohol

Downstream raw materials:

Boc-Gly-Aib-OBzl

Boc-L-Pro-Aib-OBzl

Boc-Val-Aib-OBzl

Boc-Leu-Aib-OBzl

Refernces

• 1、 -. "Antiviral phosphoramidates". Page/Page column 18; 21. . Retrieved 2008/06/13.
• 2、 -. "CHEMICAL COMPOUNDS". Page/Page column 22-23. . Retrieved 2010/02/10.