1-[1-(4-Nitrophenyl)cyclohexyl]piperidine

Base Information

• Chemical Name: 1-[1-(4-Nitrophenyl)cyclohexyl]piperidine
• CAS No.: 60658-01-7
• Molecular Formula: C17H24N2O2
• Molecular Weight: 288.39
• DSSTox Substance ID: DTXSID60499178
• Nikkaji Number: J275.185B
• Wikidata: Q82349733
• Mol file: 60658-01-7.mol

Synonyms:1-[1-(4-Nitrophenyl)cyclohexyl]piperidine;60658-01-7;DTXSID60499178

Chemical Property of 1-[1-(4-Nitrophenyl)cyclohexyl]piperidine

Chemical Property:

• XLogP3: 3.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 288.183778013
• Heavy Atom Count: 21
• Complexity: 346

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCC(CC1)(C2=CC=C(C=C2)[N+](=O)[O-])N3CCCCC3

Technology Process of 1-[1-(4-Nitrophenyl)cyclohexyl]piperidine

There total 2 articles about 1-[1-(4-Nitrophenyl)cyclohexyl]piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

Phencyclidine (77-10-1) → 3-nitrophencyclidine (70227-29-1) + 4-nitrophencyclidine (60658-01-7)

Guidance literature:

With sulfuric acid; nitric acid; Yields of byproduct given; 1.) 0 deg C, 2.) 25 deg C, 1 h;

DOI:10.1021/jo00323a014

Reference yield:

→ 4-nitrophencyclidine (60658-01-7)

Guidance literature:

Phencyclidin (III), H2SO4-HNO3;

Reference yield:

4-nitrophencyclidine (60658-01-7) → 4,4'-bis<1-(1-piperidyl)cyclohexyl>azobenzene (76916-10-4)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; Heating;

DOI:10.1021/jo00323a014

upstream raw materials:

Phencyclidine

Downstream raw materials:

4,4'-bis<1-(1-piperidyl)cyclohexyl>azobenzene

Refernces