(2,6-Diethylphenyl)boronic acid

Base Information

• Chemical Name: (2,6-Diethylphenyl)boronic acid
• CAS No.: 610286-39-0
• Molecular Formula: C10H15BO2
• Molecular Weight: 178.039
• European Community (EC) Number: 853-215-4
• DSSTox Substance ID: DTXSID70593772
• Nikkaji Number: J2.114.816D
• Wikidata: Q82488319
• Mol file: 610286-39-0.mol

Synonyms:(2,6-diethylphenyl)boronic acid;610286-39-0;Boronic acid, (2,6-diethylphenyl)-;2,6-diethylphenylboronic acid;starbld0019208;SCHEMBL61590;2,6-diethylphenyl boronic acid;2,6-diethyl-phenyl boronic acid;DTXSID70593772;GOMOOVJOVBVJLF-UHFFFAOYSA-N;AKOS006309442;Boronic acid, B-(2,6-diethylphenyl)-;WS-02135;CS-0312023;D85809;EN300-2585784;Z1198306674

Chemical Property of (2,6-Diethylphenyl)boronic acid

Chemical Property:

• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 178.1165099
• Heavy Atom Count: 13
• Complexity: 138

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: B(C1=C(C=CC=C1CC)CC)(O)O

Technology Process of (2,6-Diethylphenyl)boronic acid

There total 4 articles about (2,6-Diethylphenyl)boronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,3-diethyl-2-bromobenzene (65232-57-7) → (2,6-diethylphenyl)boronic acid (610286-39-0)

Guidance literature:

1,3-diethyl-2-bromobenzene; With n-butyllithium; In tetrahydrofuran; cyclohexane; at -75 ℃; for 1.5h;

With Trimethyl borate; In tetrahydrofuran; cyclohexane; at -75 - 20 ℃;

With hydrogenchloride; In tetrahydrofuran; cyclohexane; water; for 1h;

Reference yield:

2-chloro-1,3-diethylbenzene → (2,6-diethylphenyl)boronic acid (610286-39-0)

Guidance literature:

With methanol; tetrakis(dimethylamido)diborane; chloro(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2′-amino-1,1′-biphenyl)]palladium(II); potassium acetate; XPhos; at 20 - 60 ℃; for 22.0833h; Inert atmosphere; Sealed tube;

DOI:10.1021/ol302124j

Reference yield:

C12H19BO2 → (2,6-diethylphenyl)boronic acid (610286-39-0)

Guidance literature:

With hydrogenchloride; water; at 20 ℃; for 3h; Inert atmosphere;

DOI:10.1021/ol502270q

upstream raw materials:

1,3-diethyl-2-bromobenzene

2,6-diethylaniline

Downstream raw materials:

potassium (2,6-diethylphenyl)trifluoroborate

2-(2,6-diethyl-phenyl)-6-methyl-5-{[methyl-(1S)-(1,2,3,4-tetrahydro-naphthalen-1-yl)-amino]-methyl}-pyrimidin-4-ol

2-(2,6-dimethylphenyl)-5-[(5-isopropyl-2-methylphenoxy)methyl]-6-methylpyrimidin-4-ol

Refernces

• 1、 Usui, Kazuteru,Tanoue, Kensuke,Yamamoto, Kosuke,Shimizu, Takashi,Suemune, Hiroshi. "Synthesis of substituted azulenes via Pt(II)-Catalyzed ring-expanding cycloisomerization". . p. 4662 - 4665. Retrieved 2015/01/16.
• 2、 -. "3-ARYL-5,6-DISUBSTITUTED PYRIDAZINES". Page/Page column 51. . Retrieved 2010/02/15.