alpha-(2-AMinophenyl)benzylaMine

Base Information

• Chemical Name: alpha-(2-AMinophenyl)benzylaMine
• CAS No.: 61057-85-0
• Molecular Formula: C13H14N2
• Molecular Weight: 198.268
• Mol file: 61057-85-0.mol

Synonyms:2-Amino-benzhydrylamin;2-aminobenzhydrylamine;

Chemical Property of alpha-(2-AMinophenyl)benzylaMine

Chemical Property:

• PSA: 52.04000
• LogP: 3.59840

Purity/Quality:

99%, ^*data from raw suppliers

α-(2-Aminophenyl)benzylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of alpha-(2-AMinophenyl)benzylaMine

There total 5 articles about alpha-(2-AMinophenyl)benzylaMine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

1-(2-Aminophenyl)-1-phenyl-methanonoxim (51674-05-6) → 2-Amino-benzhydrylamin (61057-85-0)

Guidance literature:

With ammonium acetate; zinc; In ammonium hydroxide; ethanol; for 3h; Heating;

Reference yield:

2CHF3O3S*C13H12N2 → 2-Amino-benzhydrylamin (61057-85-0)

Guidance literature:

2CHF₃O₃S*C₁₃H₁₂N₂; With sodium tetrahydroborate; In methanol; dichloromethane; at 20 ℃; Cooling with ice; Inert atmosphere;

With sodium hydroxide; In methanol; dichloromethane; water; Cooling with ice; Inert atmosphere;

DOI:10.1016/j.tet.2011.04.038

Reference yield:

anthranilic acid nitrile (1885-29-6) → 2-Amino-benzhydrylamin (61057-85-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: dichloromethane / 60 - 80 °C / Inert atmosphere

2.1: sodium tetrahydroborate / methanol; dichloromethane / 20 °C / Cooling with ice; Inert atmosphere

2.2: Cooling with ice; Inert atmosphere

With sodium tetrahydroborate; In methanol; dichloromethane;

DOI:10.1016/j.tet.2011.04.038

upstream raw materials:

1-(2-Aminophenyl)-1-phenyl-methanonoxim

anthranilic acid nitrile

benzene

Downstream raw materials:

2-(2-Chloro-phenyl)-4-phenyl-1,2,3,4-tetrahydro-quinazoline

2-(4-Nitro-phenyl)-4-phenyl-1,2,3,4-tetrahydro-quinazoline

2-Methyl-2,4-diphenyl-1,2,3,4-tetrahydro-quinazoline

2-(2-Methoxy-phenyl)-4-phenyl-1,2,3,4-tetrahydro-quinazoline

Refernces

• 1、 Kempter, G.,Ehrlichmann, W.,Plesse, M.,Lehm, H.-U.. "1,3-Unsubstituted 1,2,3,4-Tetrahydroquinazolines from 1,3-Diamines". . p. 832 - 840. Retrieved 2007/10/02.