2-Naphthylhydrazine hydrochloride

Base Information

• Chemical Name: 2-Naphthylhydrazine hydrochloride
• CAS No.: 2243-58-5
• Molecular Formula: C10H10N2^.HCl
• Molecular Weight: 194.664
• Hs Code.: 2928000090
• Mol file: 2243-58-5.mol

Synonyms:Hydrazine,(2-naphthyl)-, hydrochloride (6CI,7CI,8CI);Hydrazine, 2-naphthalenyl-,monohydrochloride (9CI);2-Hydrazinonaphthalene monohydrochloride;2-naphthalenyl hydrazine hydrochloride;

Chemical Property of 2-Naphthylhydrazine hydrochloride

Chemical Property:

• Vapor Pressure: 1.87E-05mmHg at 25°C
• Melting Point: 123 °C
• Boiling Point: 362.9 °C at 760 mmHg
• Flash Point: 203.9 °C
• PSA: 38.05000
• Density: 1.215g/cm3
• LogP: 3.70070
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility.: DMSO (Slightly), Water (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

2-NaphthylhydrazineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Naphthylhydrazine Hydrochloride acts as a reagent in the synthesis and biological activity of some new pyrazoline and pyrimidine derivatives as antibacterial and antifungal agents. Synthesis and biological evaluation of 6-hydroxypyridazinone derivatives as σ1 receptor ligands for treating neuropathic pain.

Technology Process of 2-Naphthylhydrazine hydrochloride

There total 5 articles about 2-Naphthylhydrazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2-bromonaphthalene (580-13-2) → 2-naphthylhydrazine hydrochloride (2243-58-5)

Guidance literature:

2-bromonaphthalene; With potassium phosphate; copper(l) iodide; N,N′-bis(2,6-dimethylphenyl)oxalamide; cetyltrimethylammonim bromide; In water; at 80 ℃; for 0.25h; Schlenk technique; Inert atmosphere; Sealed tube;

With hydrazine hydrate; In water; at 80 ℃; Inert atmosphere; Schlenk technique; Sealed tube;

With hydrogenchloride; In water; pH=3 - 4; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1002/cjoc.201800326

Reference yield: 63.0%

naphthalen-2-ylamine (91-59-8) → 2-naphthylhydrazine hydrochloride (2243-58-5)

Guidance literature:

naphthalen-2-ylamine; With hydrogenchloride; sodium nitrite; In water; for 1h; Cooling with ice;

With tin(ll) chloride; In water; for 3.5h; Cooling with ice;

Reference yield:

di-tert-butyl 1-(naphthalene-2-yl)hydrazine-1,2-dicarboxylate (868394-40-5) → 2-naphthylhydrazine hydrochloride (2243-58-5)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; isopropyl alcohol; at 60 ℃; for 0.5h;

DOI:10.1021/jm020057r

upstream raw materials:

naphthalen-2-ylamine

di-tert-butyl 1-(naphthalene-2-yl)hydrazine-1,2-dicarboxylate

2-bromonaphthalene

β-naphthol

Downstream raw materials:

9-methyl-12,13-dihydro-7H-dibenzo[a,g]carbazole

2,3-dimethylbenz<4,5>indole

7,8,9,11-tetrahydrobenzo[c]carbazole

7H-dibenzo[c,g]carbazole

Refernces

• 1、 -. "A 10 - bromo - 7H - benzo [c] carbazole preparation method (by machine translation)". Paragraph 0091; 0095. . Retrieved 2019/10/17.
• 2、 Koetzner, Lisa,Webber, Matthew J.,Martinez, Alberto,Defusco, Claudia,List, Benjamin. "Asymmetric catalysis on the nanoscale: The organocatalytic approach to helicenes". supporting information. p. 5202 - 5205. Retrieved 2014/05/20.