5-(Dimethylamino)-2,1,3-benzoxadiazole

Base Information

• Chemical Name: 5-(Dimethylamino)-2,1,3-benzoxadiazole
• CAS No.: 6124-22-7
• Molecular Formula: C8H9N3O
• Molecular Weight: 163.17700
• Hs Code.: 2934999090
• Mol file: 6124-22-7.mol

Synonyms:5-Dimethylamino-benzofurazan;2,1,3-Benzoxadiazol-5-amine,N,N-dimethyl;

Chemical Property of 5-(Dimethylamino)-2,1,3-benzoxadiazole

Chemical Property:

• PSA: 42.16000
• LogP: 1.28880

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(Dimethylamino)-2,1,3-benzoxadiazole

There total 7 articles about 5-(Dimethylamino)-2,1,3-benzoxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

dimethyl amine (124-40-3) + 5-fluoro-2,1,3-benzoxadiazole (149440-45-9) → 5-Dimethylamino-benzofurazan (6124-22-7)

Guidance literature:

In water; acetonitrile; at 20 ℃; for 72h;

DOI:10.1039/b202367a

Reference yield:

dimethyl-(1-oxy-benzo[1,2,5]oxadiazol-5-yl)-amine (3751-45-9) → 5-Dimethylamino-benzofurazan (6124-22-7)

Guidance literature:

With triethyl phosphite; In ethanol;

DOI:10.1021/jm00308a027

Reference yield:

2-nitro-4-fluoroaniline (364-78-3) → 5-Dimethylamino-benzofurazan (6124-22-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 84 percent / potassium hydroxide; sodium hypochlorite / ethanol; H₂O / 0.33 h / 20 °C

2: triphenylphosphine / chlorobenzene / 0.33 h / 20 °C

3: 69 percent / acetonitrile; H₂O / 72 h / 20 °C

With potassium hydroxide; sodium hypochlorite; triphenylphosphine; In ethanol; water; chlorobenzene; acetonitrile;

DOI:10.1039/b202367a

upstream raw materials:

dimethyl-(1-oxy-benzo[1,2,5]oxadiazol-5-yl)-amine

dimethyl amine

5-fluoro-2,1,3-benzoxadiazole

2-nitro-4-fluoroaniline

Refernces