α-AMino-2-thiopheneacetonitrile

Base Information

• Chemical Name: α-AMino-2-thiopheneacetonitrile
• CAS No.: 61261-50-5
• Molecular Formula: C6H6N2S
• Molecular Weight: 138.19000
• Mol file: 61261-50-5.mol

Synonyms:α-Amino-2-thiopheneacetonitrile;Amino-thiophen-2-yl-acetonitrile;alfa-Amino-2-thiopheneacetonitrile;Alpha-Amino-2-thiopheneacetonitrile;α-cyano-2-thiophenemethylamine;DL-2-[cyano(amino)methyl]thiophene;2-amino-2-(2-thienyl)acetonitrile;

Chemical Property of α-AMino-2-thiopheneacetonitrile

Chemical Property:

• PSA: 78.05000
• LogP: 1.97178
• Solubility.: Chloroform, DCM, Ethyl Acetate

Purity/Quality:

98% ^*data from raw suppliers

α-Amino-2-thiopheneacetonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: α-Amino-2-thiopheneacetonitrile is an intermediate in the synthesis of Ethaboxam (E675700), a fungicide used against fungal infections in crops.

Technology Process of α-AMino-2-thiopheneacetonitrile

There total 6 articles about α-AMino-2-thiopheneacetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

thiophene-2-carbaldehyde (98-03-3) + 2-hydroxy-2-methylpropanenitrile (75-86-5) → 2-amino-2-(thiophene-2-yl)acetonitrile (61261-50-5)

Guidance literature:

thiophene-2-carbaldehyde; With lithium hexamethyldisilazane; In tetrahydrofuran; at 25 ℃; for 4h;

2-hydroxy-2-methylpropanenitrile; In tetrahydrofuran; at 25 ℃; for 12h;

DOI:10.1081/SCC-200043270

Reference yield: 60.0%

thiophene-2-carbaldehyde (98-03-3) + trimethylsilyl cyanide (7677-24-9) → 2-amino-2-(thiophene-2-yl)acetonitrile (61261-50-5)

Guidance literature:

thiophene-2-carbaldehyde; With ammonia; In methanol;

trimethylsilyl cyanide; In methanol; at 0 - 45 ℃; for 5.33333h;

DOI:10.1021/jo900425w

Reference yield: 60.0%

trimethylsilyl cyanide (7677-24-9) + N-(Trimethylsilyl)thiophene-2-carbaldehyde (107768-97-8) → 2-amino-2-(thiophene-2-yl)acetonitrile (61261-50-5)

Guidance literature:

In diethyl ether; at 20 ℃; for 0.5h;

DOI:10.1039/a808424f

upstream raw materials:

trimethylsilyl cyanide

N-(Trimethylsilyl)thiophene-2-carbaldehyde

thiophene-2-carbaldehyde

2-hydroxy-2-methylpropanenitrile

Downstream raw materials:

2-(4-chlorophenyl)-N-(cyano(thiophene-2-yl)methyl)acetamide

Refernces

• 1、 Thompson, Mark J.,Adams, Harry,Chen, Beining. "Development of a diversity-oriented approach to oxazole-5-amide libraries". experimental part. p. 3856 - 3865. Retrieved 2009/09/29.
• 2、 Saidi, Mohammad R.,Javanshir, Shahrzad,Mojtahedi, Mohammad M.. "Lithium perchlorate mediated three component reaction for the preparation of primary amines". . p. 330 - 331. Retrieved 2007/10/03.