Linsidomine hydrochloride

Base Information Edit

Chemical Name:Linsidomine hydrochloride
CAS No.:16142-27-1
Deprecated CAS:25800-18-4
Molecular Formula:C6H11N4O2^.Cl
Molecular Weight:206.632
Hs Code.:29349990
European Community (EC) Number:605-254-1
UNII:Y0054U597M
DSSTox Substance ID:DTXSID9049039
Wikidata:Q27294078
ChEMBL ID:CHEMBL2361429
Mol file:16142-27-1.mol

Synonyms:SIN-1 hydrochloride;SIN-1 Chloride;SIN-1 HCl;3-Morpholino Sydnonimine Hydrochloride;Linsidomine (hydrochloride);3-Morpholinosydnonimine, HCl;DTXSID9049039;1,2,3-Oxadiazolium, 5-amino-3-(4-morpholinyl)-, chloride (1:1);3-morpholin-4-yloxadiazol-3-ium-5-amine;chloride;3-Morpholinosydnone imine hydrochloride;Y0054U597M;Sydnone imine, 3-morpholino-, monohydrochloride;DTXCID4028965;CAS-16142-27-1;NCGC00024772-01;SR-01000076020;SCHEMBL445422;SCHEMBL7616002;SCHEMBL8511764;CHEMBL2361429;3-Morpholinylsydnoneimine chloride;Tox21_113577;AKOS005166851;Tox21_113577_1;LINSIDOMINE HYDROCHLORIDE [MART.];NCGC00024772-02;AC-18751;LINSIDOMINE HYDROCHLORIDE [WHO-DD];HY-101200;LS-148401;CS-0020976;F87148;SR-01000076020-3;Q27294078;5-Amino-3-morpholin-4-yl-[1,2,3]oxadiazol-3-ium;5-Amino-3-morpholin-4-yl-1,2,3-oxadiazolidin-3-ium chloride

Suppliers and Price of Linsidomine hydrochloride

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
SIN-1 chloride
10mg
$ 277.00

TRC
3-Morpholinosydnonimine hydrochloride
25mg
$ 100.00

Tocris
SIN-1chloride ≥98%(HPLC)
50
$ 161.00

Sigma-Aldrich
SIN-1, Hydrochloride Nitric oxide (NO) donor.
20mg
$ 119.32

Sigma-Aldrich
3-Morpholinosydnonimine hydrochloride (consistent with structure, NMR)
25mg
$ 190.00

Sigma-Aldrich
3-Morpholinosydnonimine hydrochloride (consistent with structure, NMR)
100mg
$ 636.00

Medical Isotopes, Inc.
3-Morpholinosydnonimine hydrochloride 94%
25 mg
$ 590.00

Cayman Chemical
SIN-1 (chloride) ≥99%
50mg
$ 106.00

Cayman Chemical
SIN-1 (chloride) ≥99%
100mg
$ 163.00

Cayman Chemical
SIN-1 (chloride) ≥99%
10mg
$ 25.00

Total 43 raw suppliers

Chemical Property of Linsidomine hydrochloride Edit

Chemical Property:

Appearance/Colour:White crystalline solid
Melting Point:186 °C
PSA：67.28000
Density:1.303 at 20℃
LogP:-0.10950
Storage Temp.:-20°C
Solubility.:Soluble in DMSO (up to 35 mg/ml) or in Water (up to 65 mg/ml)
Water Solubility.:soluble
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:1
Exact Mass:206.0570533
Heavy Atom Count:13
Complexity:151

Purity/Quality:

99.9% ^*data from raw suppliers

SIN-1 chloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:C1COCCN1[N+]2=NOC(=C2)N.[Cl-]
Description As the active metabolite of molsidomine, SIN-1 (chloride) is a potent vasorelaxant and inhibitor of platelet aggregation. It produces both NO and superoxide and can therefore be used to generate peroxynitrite under physiological conditions.
Uses SIN-1 is a metabolite of the vasodilator molsidomine and is considered to be a peroxynitrite releasing compound 3-Morpholinosydnonimine hydrochloride is a metabolite of the vasodilator Molsidomine (M488002) and is considered to be a peroxynitrite releasing compound. Molsidomine Impurity A. 3-Morpholinosydnonimine hydrochloride has been used:as a peroxynitrite donor standard to study the accumulation of peroxynitrite?in?Arabidopsis thalianato study its effects on nitrosative stress in human brain vascular pericytes and human embryonic kidney cellsas a ROS to study its effects on mouse embryonic fibroblasts
Indications Linsidomine (SIN-1) is an active metabolite of the antianginal drug molsidomine. Its mechanism of action upon the corpus cavernosum involves the release of nitric oxide. Injected intracavernosally it can produce penile erections, but its clinical usefulness has not been fully established.

Technology Process of Linsidomine hydrochloride

There total 1 articles about Linsidomine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: