(2Z)-(2,4-DIOXO-1,3-THIAZOLIDIN-5-YLIDENE)ACETIC ACID

Base Information

• Chemical Name: (2Z)-(2,4-DIOXO-1,3-THIAZOLIDIN-5-YLIDENE)ACETIC ACID
• CAS No.: 5374-29-8
• Molecular Formula: C₅H₃NO₄S
• Molecular Weight: 173.149
• Mol file: 5374-29-8.mol

Synonyms:(2Z)-(2,4-DIOXO-1,3-THIAZOLIDIN-5-YLIDENE)ACETIC ACID 95%;

Chemical Property of (2Z)-(2,4-DIOXO-1,3-THIAZOLIDIN-5-YLIDENE)ACETIC ACID

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 108.77000
• Density: g/cm³
• LogP: 0.26670

Purity/Quality:

98%Min ^*data from raw suppliers

2-[(5Z)-2,4-dioxo-1,3-thiazolidin-5-ylidene]aceticacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (2Z)-(2,4-DIOXO-1,3-THIAZOLIDIN-5-YLIDENE)ACETIC ACID

There total 3 articles about (2Z)-(2,4-DIOXO-1,3-THIAZOLIDIN-5-YLIDENE)ACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2,4-dioxothiazolidin-5-yl)acetic acid (875-97-8) → (2,4-dioxo-thiazolidin-5-ylidene)-acetic acid (5374-29-8)

Guidance literature:

With bromine; In acetic acid;

DOI:10.1139/v60-178

Reference yield:

(4-oxo-2-thioxo-thiazolidin-5-ylidene)-acetic acid (5316-60-9) → (2,4-dioxo-thiazolidin-5-ylidene)-acetic acid (5374-29-8)

Guidance literature:

With mercury(II) oxide; In water;

Reference yield:

(4-oxo-2-thioxo-thiazolidin-5-yl)-acetic acid (701-23-5) → (2,4-dioxo-thiazolidin-5-ylidene)-acetic acid (5374-29-8)

Guidance literature:

Multi-step reaction with 2 steps

1: Br₂ / acetic acid

2: HgO / H₂O

With bromine; mercury(II) oxide; In water; acetic acid;

upstream raw materials:

2-(2,4-dioxothiazolidin-5-yl)acetic acid

(4-oxo-2-thioxo-thiazolidin-5-ylidene)-acetic acid

(4-oxo-2-thioxo-thiazolidin-5-yl)-acetic acid

Downstream raw materials:

2-(2,4-dioxothiazolidin-5-yl)acetic acid

N-(thiazol-2-yl)-2-(2,4-dioxothiazolidin-5-ylidene)acetamide

Refernces

• 1、 Kaminskyy, Danylo,Bednarczyk-Cwynar, Barbara,Vasylenko, Olexandr,Kazakova, Oxana,Zimenkovsky, Borys,Zaprutko, Lucjusz,Lesyk, Roman. "Synthesis of new potential anticancer agents based on 4-thiazolidinone and oleanane scaffolds". . p. 3568 - 3580. Retrieved 2013/03/13.