Leucine 2-naphthylamide hydrochloride

Base Information

• Chemical Name: Leucine 2-naphthylamide hydrochloride
• CAS No.: 893-36-7
• Molecular Formula: C16H20 N2 O . Cl H
• Molecular Weight: 292.809
• Hs Code.: 2924299090
• European Community (EC) Number: 212-970-4
• UNII: 4D5484D61M
• DSSTox Substance ID: DTXSID90237606
• Wikidata: Q27259431
• Mol file: 893-36-7.mol

Synonyms:893-36-7;Leucine 2-naphthylamide hydrochloride;L-Leucine beta-naphthylamide hydrochloride;(S)-2-Amino-4-methyl-N-(naphthalen-2-yl)pentanamide hydrochloride;h-leu-betana hcl;4D5484D61M;L-Leucyl-2-naphthylamide Hydrochloride;N(1)-2-Naphthylleucinamide hydrochloride;(S)-2-Amino-4-methyl-N-2-naphthylvaleramide monohydrochloride;L-Leucine |A-naphthylamide (hydrochloride);(2S)-2-amino-4-methyl-N-naphthalen-2-ylpentanamide;hydrochloride;UNII-4D5484D61M;EINECS 212-970-4;L-Leucine-2-naphthylamide hydrochloride;H-Leu-NA HCl;L-Leu-betaNA⋅HCl;SCHEMBL10600620;DTXSID90237606;HTHKKWZMEVJWQF-RSAXXLAASA-N;MFCD00034972;AKOS016013094;l-leucyl-6-naphthylamine hydrochloride;FD21935;HY-119150A;AS-49250;CS-0137963;L0037;LEUCINE-2-NAPHTHYLAMIDE HYDROCHLORIDE;L-3000;EN300-7388090;Q27259431;(2S)-2-AMINO-4-METHYL-N-(NAPHTHALEN-2-YL)PENTANAMIDE HYDROCHLORIDE;L-Leucine beta-naphthylamide hydrochloride, leucine aminopeptidase substrate;PENTANAMIDE, 2-AMINO-4-METHYL-N-2-NAPHTHALENYL-, HYDROCHLORIDE (1:1), (2S)-;PENTANAMIDE, 2-AMINO-4-METHYL-N-2-NAPHTHALENYL-, MONOHYDROCHLORIDE, (2S)-;PENTANAMIDE, 2-AMINO-4-METHYL-N-2-NAPHTHALENYL-, MONOHYDROCHLORIDE, (S)-;VALERAMIDE, 2-AMINO-4-METHYL-N-2-NAPHTHYL-, MONOHYDROCHLORIDE, (S)-

Chemical Property of Leucine 2-naphthylamide hydrochloride

Chemical Property:

• Vapor Pressure: 6.76E-09mmHg at 25°C
• Melting Point: 255-260 °C (dec.)
• Refractive Index: 90 ° (C=1, H2O)
• Boiling Point: 467°C at 760 mmHg
• Flash Point: 236.2°C
• PSA: 55.12000
• LogP: 4.72700
• Storage Temp.: −20°C
• Solubility.: H2O: soluble
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 292.1342410
• Heavy Atom Count: 20
• Complexity: 303

Purity/Quality:

98%,99%, ^*data from raw suppliers

L-Leucine b-naphthylamide hydrochloride ^*data from reagent suppliers

Safty Information:

• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(C)CC(C(=O)NC1=CC2=CC=CC=C2C=C1)N.Cl
• Isomeric SMILES: CC(C)C[C@@H](C(=O)NC1=CC2=CC=CC=C2C=C1)N.Cl
• Uses: Substrate for the assay of leucine-aminopeptidase. Substrate for leucine aminopeptidase determination in colorimetric and histochemical procedures.

Technology Process of Leucine 2-naphthylamide hydrochloride

There total 3 articles about Leucine 2-naphthylamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

[(S)-3-Methyl-1-(naphthalen-2-ylcarbamoyl)-butyl]-carbamic acid tert-butyl ester (114684-54-7) → H-L-Leu-β-naphthylamide hydrochloride (893-36-7)

Guidance literature:

With hydrogenchloride; In ethyl acetate; for 2h; Ambient temperature;

DOI:10.1248/cpb.35.2698

Reference yield:

N-tert-butoxycarbonyl-L-leucine (13139-15-6,53296-34-7) → H-L-Leu-β-naphthylamide hydrochloride (893-36-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) diphenyl phosphorazidate, triethylamine / 1.) 1,2-dichloroethane, room temp., 2 h, then reflux, 15 min; 2.) 1,2-dichloroethane, reflux, 6 h

2: 78 percent / 10percent hydrogen chloride / ethyl acetate / 2 h / Ambient temperature

With hydrogenchloride; diphenyl phosphoryl azide; triethylamine; In ethyl acetate;

DOI:10.1248/cpb.35.2698

Reference yield:

naphthalene-2-carboxylate (93-09-4) → H-L-Leu-β-naphthylamide hydrochloride (893-36-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) diphenyl phosphorazidate, triethylamine / 1.) 1,2-dichloroethane, room temp., 2 h, then reflux, 15 min; 2.) 1,2-dichloroethane, reflux, 6 h

2: 78 percent / 10percent hydrogen chloride / ethyl acetate / 2 h / Ambient temperature

With hydrogenchloride; diphenyl phosphoryl azide; triethylamine; In ethyl acetate;

DOI:10.1248/cpb.35.2698

upstream raw materials:

[(S)-3-Methyl-1-(naphthalen-2-ylcarbamoyl)-butyl]-carbamic acid tert-butyl ester

N-tert-butoxycarbonyl-L-leucine

naphthalene-2-carboxylate

Downstream raw materials:

L-leucine

naphthalen-2-ylamine

Refernces