Benzenehexanol, methanesulfonate

Base Information

• Chemical Name: Benzenehexanol, methanesulfonate
• CAS No.: 61440-48-0
• Molecular Formula: C13H20O3S
• Molecular Weight: 256.366
• Mol file: 61440-48-0.mol

Synonyms:

Chemical Property of Benzenehexanol, methanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenehexanol, methanesulfonate

There total 6 articles about Benzenehexanol, methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-phenyl-1-hexanol (2430-16-2) + methanesulfonyl chloride (124-63-0) → 6-phenylhexanol methylsulfonyl ester (61440-48-0)

Guidance literature:

With triethylamine; In diethyl ether;

DOI:10.1021/jm00172a020

Reference yield:

trans 6-phenyl-5-hexenoic acid (16424-56-9) → 6-phenylhexanol methylsulfonyl ester (61440-48-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / H₂ / 5percent Pd/C / ethyl acetate / 1 h / 25 °C / 1551.4 Torr

2: 91 percent / LiAlH₄ / diethyl ether / 4 h / 25 °C

3: triethylamine (TEA) / diethyl ether

With lithium aluminium tetrahydride; hydrogen; triethylamine; palladium on activated charcoal; In diethyl ether; ethyl acetate;

DOI:10.1021/jm00172a020

Reference yield:

(4-carboxybutyl)triphenylphosphonium bromide (17814-85-6) → 6-phenylhexanol methylsulfonyl ester (61440-48-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) lithium hexamethyldisilazide / 1.) THF, hexane, 25 deg C, 1 h, 2.) 25 deg C, 2 h

2: 95 percent / H₂ / 5percent Pd/C / ethyl acetate / 1 h / 25 °C / 1551.4 Torr

3: 91 percent / LiAlH₄ / diethyl ether / 4 h / 25 °C

4: triethylamine (TEA) / diethyl ether

With lithium aluminium tetrahydride; hydrogen; triethylamine; lithium hexamethyldisilazane; palladium on activated charcoal; In diethyl ether; ethyl acetate;

DOI:10.1021/jm00172a020

upstream raw materials:

6-phenyl-1-hexanol

methanesulfonyl chloride

6-phenylhexanic acid

trans 6-phenyl-5-hexenoic acid

Downstream raw materials:

ethyl 2-<(6-phenylhexyl)oxy>-5-nitrobenzenepropanoate

ethyl 4-(6-phenylhexylamino)benzoate

6-phenyl-1-hexyl iodide

5-(3-carboxybenzoyl)-2-<(6-phenylhexyl)oxy>benzenepropanoic acid

Refernces

• 1、 -. "ALIPHATIC AMINO BIS-ARYL SQUALENE SYNTHASE INHIBITORS". . . Retrieved 2008/06/13.
• 2、 -. "Antilipidemic para-[aryl(alkyl or alkenyl)amino]-benzoic acid derivatives". . . Retrieved 2008/06/13.