Phosphonic acid, (1-methyl-2-oxo-2-phenylethyl)-, dimethyl ester

Base Information

• Chemical Name: Phosphonic acid, (1-methyl-2-oxo-2-phenylethyl)-, dimethyl ester
• CAS No.: 61463-81-8
• Molecular Formula: C11H15O4P
• Molecular Weight: 242.211
• Mol file: 61463-81-8.mol

Synonyms:

Chemical Property of Phosphonic acid, (1-methyl-2-oxo-2-phenylethyl)-, dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Phosphonic acid, (1-methyl-2-oxo-2-phenylethyl)-, dimethyl ester

There total 1 articles about Phosphonic acid, (1-methyl-2-oxo-2-phenylethyl)-, dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzoic acid methyl ester (93-58-3,5705-52-2,80226-58-0) → dimethyl (1-methyl-2-oxo-2-phenylethyl)phosphonate (61463-81-8)

Guidance literature:

Multi-step reaction with 2 steps

1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -5 °C / Inert atmosphere

2: potassium carbonate / acetone / 24 h / 20 °C

With potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; acetone;

DOI:10.1039/d0ob00379d

Reference yield: 59.0%

Togni's reagent II (887144-94-7) + dimethyl (1-methyl-2-oxo-2-phenylethyl)phosphonate (61463-81-8) → dimethyl (1-trifluoromethyl-1-methyl-2-oxo-2-phenylethyl)phosphonate

Guidance literature:

dimethyl (1-methyl-2-oxo-2-phenylethyl)phosphonate; With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium t-butanolate; In dichloromethane; at 0 ℃; for 0.5h; Schlenk technique; Inert atmosphere;

Togni's reagent II; In dichloromethane; at 20 ℃; for 18h; Schlenk technique; Inert atmosphere;

DOI:10.1080/00397911.2016.1139724

Reference yield: 42.0%

dimethyl (1-methyl-2-oxo-2-phenylethyl)phosphonate (61463-81-8) + 4-n-methylphenylacetylene (766-97-2) → 2-methoxy-3-methyl-4-(4-tolyl)-6-phenyl-1,2-oxaphosphorin 2-oxide + dimethyl (E)-[1-methyl-4-oxo-4-phenyl-2-(4-tolyl)-butenyl]phosphonate

Guidance literature:

dimethyl (1-methyl-2-oxo-2-phenylethyl)phosphonate; 4-n-methylphenylacetylene; With decacarbonyldirhenium⁽⁰⁾; In toluene; at 120 ℃; for 24h; Inert atmosphere; Sealed tube;

In toluene; at 160 ℃; for 8h; stereoselective reaction; Inert atmosphere; Sealed tube;

DOI:10.1021/ol502859w

upstream raw materials:

benzoic acid methyl ester

Refernces