L-Tyrosylglycylglycyl-L-phenylalanyl-D-methionine

Base Information

• Chemical Name: L-Tyrosylglycylglycyl-L-phenylalanyl-D-methionine
• CAS No.: 61600-30-4
• Molecular Formula: C₂₇H₃₅N₅O₇S
• Molecular Weight: 573.67
• DSSTox Substance ID: DTXSID00510134
• Wikidata: Q82368224
• Mol file: 61600-30-4.mol

Synonyms:L-Tyrosylglycylglycyl-L-phenylalanyl-D-methionine;61600-30-4;DTXSID00510134

Chemical Property of L-Tyrosylglycylglycyl-L-phenylalanyl-D-methionine

Chemical Property:

• XLogP3: -2.1
• Hydrogen Bond Donor Count: 7
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 16
• Exact Mass: 573.22571965
• Heavy Atom Count: 40
• Complexity: 847

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CSCCC(C(=O)O)NC(=O)C(CC1=CC=CC=C1)NC(=O)CNC(=O)CNC(=O)C(CC2=CC=C(C=C2)O)N
• Isomeric SMILES: CSCC[C@H](C(=O)O)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)CNC(=O)CNC(=O)[C@H](CC2=CC=C(C=C2)O)N

Technology Process of L-Tyrosylglycylglycyl-L-phenylalanyl-D-methionine

There total 2 articles about L-Tyrosylglycylglycyl-L-phenylalanyl-D-methionine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ [Met]5enkephalin (58569-55-4,61600-30-4,61600-31-5,61600-34-8)

Guidance literature:

Z-Tyr-Gly-Gly-Phe-Met-O-CH2-Ph, HF, Anisol, Diethylsulfid;

DOI:10.1021/jo00428a004

Reference yield:

Tyr-Gly-Gly-Phe-D-Met-Merrifield resin → H-Tyr-Gly-Gly-Phe-D-Met-OH (58569-55-4,61600-31-5,61600-34-8,61600-30-4)

Guidance literature:

With hydrogen bromide; acetic acid; In methoxybenzene; for 3h;

Reference yield:

[Met]5enkephalin (58569-55-4,61600-30-4,61600-31-5,61600-34-8) + copper dichloride → (NH2CH(CH2C6H4OH)(CONCH2)2CONCH(CH2C6H5)CONHCH(CH2CH2SCH3)CO2)Cu(2-)

Guidance literature:

With sodium hydroxide; In further solvent(s); fresh D2O soln. of CuCl2 containing NaCl to ionic strength 0.09 was combined with the enkephalin, pH was adjusted to basic with NaOH; detd. by UV, NMR and ESR spectra;

DOI:10.1021/ic00135a029

Refernces