2,2-Diphenyltetrahydrofuran

Base Information

• Chemical Name: 2,2-Diphenyltetrahydrofuran
• CAS No.: 887-15-0
• Molecular Formula: C16H16 O
• Molecular Weight: 224.302
• Hs Code.: 2932190090
• European Community (EC) Number: 212-957-3
• NSC Number: 89761
• DSSTox Substance ID: DTXSID70237245
• Nikkaji Number: J195.186F
• Wikidata: Q27077075
• Mol file: 887-15-0.mol

Synonyms:2,2-Diphenyltetrahydrofuran;887-15-0;2,2-diphenyloxolane;diphenyltetrahydrofuran;EINECS 212-957-3;NSC89761;2,2-di(phenyl)oxolane;D01BDJ;GTPL2498;SCHEMBL1569110;DTXSID70237245;Furan, tetrahydro-2,2-diphenyl-;NSC 89761;NSC-89761;AKOS024323254;FT-0609297;Q27077075

Chemical Property of 2,2-Diphenyltetrahydrofuran

Chemical Property:

• Vapor Pressure: 0.000181mmHg at 25°C
• Boiling Point: 339.4°C at 760 mmHg
• Flash Point: 153.6°C
• PSA: 9.23000
• Density: 1.085g/cm³
• LogP: 3.74060
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 224.120115130
• Heavy Atom Count: 17
• Complexity: 218

Purity/Quality:

99% ^*data from raw suppliers

2,2-Diphenyltetrahydrofuran ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1CC(OC1)(C2=CC=CC=C2)C3=CC=CC=C3

Technology Process of 2,2-Diphenyltetrahydrofuran

There total 19 articles about 2,2-Diphenyltetrahydrofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

1,1-diphenylbutan-1,4-diol (1023-94-5) → 2,2-diphenyl-tetrahydro-furan (887-15-0)

Guidance literature:

With iodine; triethyl phosphite; In dichloromethane; triethylamine; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1021/ol4026588

Reference yield: 82.0%

cyclopropyl diphenyl carbinol (5785-66-0) → 2,2-diphenyl-tetrahydro-furan (887-15-0) + 4,4-diphenyl-3-buten-1-ol (76694-24-1)

Guidance literature:

With 2,6-di-tert-butyl-4-methyl-phenol; bis(acetylacetonato)dioxidomolybdenum(VI); In chlorobenzene; at 80 ℃; for 48h; Further Variations:; Catalysts; Reagents; Product distribution;

DOI:10.1246/cl.2005.790

Reference yield: 80.0%

phenylmagnesium chloride (100-59-4) + 4-chloro-1-phenylbutan-1-one (939-52-6) → 2,2-diphenyl-tetrahydro-furan (887-15-0)

Guidance literature:

In tetrahydrofuran; at -40 - 20 ℃; for 24h;

DOI:10.1039/c4cc03149k

upstream raw materials:

diethyl ether

4-fluoro-butyric acid methyl ester

1,1-diphenylbutan-1,4-diol

trimethylene oxide

Downstream raw materials:

2-phenyl-2-(o-tolyl)tetrahydrofuran

2-(2-ethylphenyl)-2-phenyltetrahydrofuran

2-(2-tributylstannylphenyl)-2-phenyltetrahydrofuran

2-(2-(phenylthio)phenyl)-2-phenyltetrahydrofuran

Refernces

• 1、 Huck, Lena,De La Hoz, Antonio,Díaz-Ortiz, Angel,Alcázar, Jesus. "Grignard Reagents on a Tab: Direct Magnesium Insertion under Flow Conditions". supporting information. p. 3747 - 3750. Retrieved 2017/07/26.
• 2、 Mallardo, Valentina,Rizzi, Ruggiero,Sassone, Francesca C.,Mansueto, Rosmara,Perna, Filippo M.,Salomone, Antonio,Capriati, Vito. "Regioselective desymmetrization of diaryltetrahydrofurans via directed ortho-lithiation: An unexpected help from green chemistry". supporting information. p. 8655 - 8658. Retrieved 2014/07/22.