2-HYDROXY CHLOROACETOANILIDE

Base Information

• Chemical Name: 2-HYDROXY CHLOROACETOANILIDE
• CAS No.: 10147-68-9
• Molecular Formula: C8H8ClNO2
• Molecular Weight: 185.61
• Mol file: 10147-68-9.mol

Synonyms:2-HYDROXY CHLOROACETOANILIDE

Chemical Property of 2-HYDROXY CHLOROACETOANILIDE

Chemical Property:

• Vapor Pressure: 3.28E-06mmHg at 25°C
• Boiling Point: 376.7°C at 760 mmHg
• Flash Point: 181.6°C
• PSA: 49.33000
• Density: 1.402g/cm³
• LogP: 1.64250

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Chloro-N-(2-hydroxyphenyl)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 2-HYDROXY CHLOROACETOANILIDE

There total 3 articles about 2-HYDROXY CHLOROACETOANILIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

chloroacetyl chloride (79-04-9) + 2-amino-phenol (95-55-6) → N-(2-hydroxyphenyl)-2-chloroacetamide (10147-68-9)

Guidance literature:

With potassium carbonate; In acetone; at 0 ℃; for 7h; Reflux;

DOI:10.21608/ejchem.2019.16920.2030

Reference yield: 19.0%

2-nitrophenyl 2-chloroacetate (24265-34-7) → N-(2-hydroxyphenyl)-2-chloroacetamide (10147-68-9)

Guidance literature:

With hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; for 1h;

DOI:10.1016/j.tet.2008.04.010

Reference yield:

→ N-(2-hydroxyphenyl)-2-chloroacetamide (10147-68-9)

Guidance literature:

o-Amino-phenol, Chloracetylchlorid;

upstream raw materials:

chloroacetyl chloride

2-amino-phenol

2-nitrophenyl 2-chloroacetate

Downstream raw materials:

1-acetoxy-2-(2-chloro-acetylamino)-benzene

2-[(4-chloro-phenylsulfanyl)-methyl]-benzoxazole

1-chloroacetoxy-2-(2-chloro-acetylamino)-benzene

2-(phenylsulfanylmethyl)benzoxazole

Refernces

• 1、 Chang, Ya-Nan,Xiang, Yang,Zhang, Yue-Juan,Wang, Wen-Ming,Chen, Cheng,Oelschlaeger, Peter,Yang, Ke-Wu. "Carbamylmethyl Mercaptoacetate Thioether: A Novel Scaffold for the Development of L1 Metallo-β-lactamase Inhibitors". . p. 527 - 532. Retrieved 2017.
• 2、 Burkholder, Conrad R.,Dolbier Jr., William R.,Médebielle, Maurice. "Synthesis and reactivity of halogeno-difluoromethyl aromatics and heterocycles: Application to the synthesis of gem-difluorinated bioactive compounds". . p. 39 - 48. Retrieved 2001.
• 3、 Bedada, Endale Teju,Gemechu, Zewdu Bezu,Maria Susai, Boobalan,Ramamoorthy, R.,Taddesse, Abi M.. "Biosensitivity and Theoretical Electronic Structure Investigations on 3-(2-Hydroxyphenyl)-2-iminothiazolidin-4-one and Its Zn2+and Cd2+ Metal Complexes". . . Retrieved 2021/11/17.
• 4、 -. "Antidiabetic compounds". Page/Page column 13-14. . Retrieved 2020/06/16.