Thiocyanic acid, 2-(acetyloxy)-2-phenylethyl ester

Base Information

• Chemical Name: Thiocyanic acid, 2-(acetyloxy)-2-phenylethyl ester
• CAS No.: 61807-25-8
• Molecular Formula: C₁₁H₁₁NO₂S
• Molecular Weight: 221.28
• Mol file: 61807-25-8.mol

Synonyms:

Chemical Property of Thiocyanic acid, 2-(acetyloxy)-2-phenylethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Thiocyanic acid, 2-(acetyloxy)-2-phenylethyl ester

There total 8 articles about Thiocyanic acid, 2-(acetyloxy)-2-phenylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

styrene oxide (96-09-3) + acetic anhydride (108-24-7) + tetrabutylammonium thiocyanate (3674-54-2) → (+/-)-1-phenyl-2-thiocyanatoethyl acetate (61807-25-8) + 2-phenyl-2-thiocyanatoethyl acetate

Guidance literature:

acetic anhydride; tetrabutylammonium thiocyanate; at 60 ℃; for 0.25h; Neat (no solvent);

styrene oxide; at 60 ℃; for 3h; Neat (no solvent);

DOI:10.1139/V10-052

Reference yield: 25.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + trimethylsilyl isothiocyanate (2290-65-5) + [bis(acetoxy)iodo]benzene (3240-34-4) → (+/-)-1-phenyl-2-thiocyanatoethyl acetate (61807-25-8) + (1,2-dithiocyanatoethyl)benzene (42877-24-7) + (2,2-Bis-thiocyanato-ethyl)-benzene

Guidance literature:

In dichloromethane; Ambient temperature;

DOI:10.1016/S0040-4039(98)00629-7

Reference yield:

styrene oxide (96-09-3) + ammonium thiocyanate (1147550-11-5) + acetyl chloride (75-36-5) → (+/-)-1-phenyl-2-thiocyanatoethyl acetate (61807-25-8) + 2-phenyl-2-thiocyanatoethanol

Guidance literature:

styrene oxide; ammonium thiocyanate; With 18-crown-6 ether; In dichloromethane; acetonitrile; Heating;

acetyl chloride; for 2.5h; Heating;

With phosphate buffer; immobilized Novozym SP 435; at 17 - 20 ℃; pH=7;

DOI:10.1016/j.tetasy.2005.05.007

upstream raw materials:

styrene

thiocyanatochloride

acetic acid

thiocyanogen

Refernces

• 1、 Lukowska, Edyta,Plenkiewicz, Jan. "Lipase-catalyzed enantiomeric separation of 1-aryloxy-3-thiocyanatopropan- 2-ols: An attempt to prepare optically active thiiranes". . p. 2149 - 2156. Retrieved 2007/10/03.
• 2、 Skorobogatova, E. V.,Grudzinskaya, E. Yu.,Afanas'ev, P. S,Kartashov, V. R.,Zefirov, N. S.,Caple, R.. "KINETICS AND DOPING EFFECT IN THE ADDITION OF 2,4-DINITROPHENYLSULFENYL CHLORIDE AND DITHIOCYANOGEN TO OLEFINS". . p. 1814 - 1822. Retrieved 2007/10/02.