2-acetyl-4-chlorophenyl pyridine-3-carboxylate

Base Information

• Chemical Name: 2-acetyl-4-chlorophenyl pyridine-3-carboxylate
• CAS No.: 7209-62-3
• Molecular Formula: C14H10ClNO3
• Molecular Weight: 275.6871
• Mol file: 7209-62-3.mol

Synonyms:

Chemical Property of 2-acetyl-4-chlorophenyl pyridine-3-carboxylate

Chemical Property:

• Vapor Pressure: 2.21E-09mmHg at 25°C
• Boiling Point: 480.2°Cat760mmHg
• Flash Point: 244.2°C
• Density: 1.315g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-acetyl-4-chlorophenyl pyridine-3-carboxylate

There total 2 articles about 2-acetyl-4-chlorophenyl pyridine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

nicotinic acid (59-67-6) + 5-chloro-2-hydroxyacetophenone (1450-74-4) → Pyridin-3-carbonsaeure-(2-acetyl-4-chlor-phenylester) (7209-62-3)

Guidance literature:

With pyridine; trichlorophosphate; at 0 ℃; Sonication;

DOI:10.1002/jhet.955

Reference yield:

→ Pyridin-3-carbonsaeure-(2-acetyl-4-chlor-phenylester) (7209-62-3)

Guidance literature:

5-Chlor-2-hydroxy-acetophenon, Nicotinsaeure, POCl3, Py., Veresterung;

Reference yield:

Pyridin-3-carbonsaeure-(2-acetyl-4-chlor-phenylester) (7209-62-3) → 6-chloro-2-(pyridine-3-yl)-4H-chromen-4-one (1920-54-3)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide; pyridine / Sonication

2: acetic acid / 0.27 h / 65 °C / Sonication

With pyridine; acetic acid; potassium hydroxide;

DOI:10.1002/jhet.955

upstream raw materials:

nicotinic acid

5-chloro-2-hydroxyacetophenone

Downstream raw materials:

1-(5-chloro-2-hydroxyphenyl)-3-(pyridine-3-yl)propane-1,3-dione

6-chloro-2-(pyridine-3-yl)-4H-chromen-4-one

Refernces

• 1、 Kulkarni,Thakar. "Synthesis of some 1,5 benzodiazepines. II". . p. 279 - 282. Retrieved 2007/10/08.