6-CHLORO-2,3-DIMETHYLQUINOXALINE

Base Information

• Chemical Name: 6-CHLORO-2,3-DIMETHYLQUINOXALINE
• CAS No.: 17911-93-2
• Molecular Formula: C10H9ClN2
• Molecular Weight: 192.64
• Hs Code.: 2933990090
• Mol file: 17911-93-2.mol

Synonyms:6-Chloro-2,3-dimethylquinoxaline;NSC 38597;

Chemical Property of 6-CHLORO-2,3-DIMETHYLQUINOXALINE

Chemical Property:

• Vapor Pressure: 0.00308mmHg at 25°C
• Refractive Index: 1.627
• Boiling Point: 293.1 °C at 760 mmHg
• Flash Point: 158.9 °C
• PSA: 25.78000
• Density: 1.246 g/cm³
• LogP: 2.90000

Purity/Quality:

99% ^*data from raw suppliers

2,3-DIMETHYL-6-CHLOROQUINOXALINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-CHLORO-2,3-DIMETHYLQUINOXALINE

There total 8 articles about 6-CHLORO-2,3-DIMETHYLQUINOXALINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-Chloro-1,2-phenylenediamine (95-83-0) + dimethylglyoxal (431-03-8) → 6-chloro-2,3-dimethyl-quinoxaline (17911-93-2)

Guidance literature:

With zirconium(IV) chloride; In methanol; at 20 ℃; for 0.0833333h;

DOI:10.1007/s11243-009-9294-9

Reference yield: 98.0%

5-chloro-2-nitroaniline (1635-61-6) + 2.3-butanediol (513-85-9) → 6-chloro-2,3-dimethyl-quinoxaline (17911-93-2)

Guidance literature:

With sodium hydroxide; In toluene; at 120 ℃; for 3h; Inert atmosphere; Sealed tube; Green chemistry;

DOI:10.1021/acs.joc.0c02453

Reference yield: 95.0%

4-Chloro-1,2-phenylenediamine (95-83-0) + 2.3-butanediol (513-85-9) → 6-chloro-2,3-dimethyl-quinoxaline (17911-93-2)

Guidance literature:

With cesiumhydroxide monohydrate; C₁₇H₁₄Br₂CoN₄; In toluene; at 150 ℃; for 24h; Sealed tube; Inert atmosphere;

DOI:10.1039/c8cc02366b

upstream raw materials:

4-Chloro-1,2-phenylenediamine

dimethylglyoxal

3-hydroxy-2-butanon

5-chloro-2-nitroaniline

Downstream raw materials:

N,2,3-trimethyl-5-nitro-6-quinoxalinamine

2-amino-3,7,8-trimethylimidazo[4,5-f]quinoxaline

N,2,3-trimethyl-6-quinoxalinamine

Refernces

• 1、 Khongkow, Pasarat,Lomlim, Luelak,Nualnoi, Teerapat,Saetang, Jirakrit,Suwanhom, Paptawan,Tipmanee, Varomyalin. "Synthesis, biological evaluation, and in silico studies of new acetylcholinesterase inhibitors based on quinoxaline scaffold". . . Retrieved 2021/08/20.
• 2、 Wang, Yan-Bing,Shi, Linlin,Zhang, Xiaojie,Fu, Lian-Rong,Hu, Weinan,Zhang, Wenjing,Zhu, Xinju,Hao, Xin-Qi,Song, Mao-Ping. "NaOH-Mediated Direct Synthesis of Quinoxalines from o-Nitroanilines and Alcohols via a Hydrogen-Transfer Strategy". . p. 947 - 958. Retrieved 2021/01/14.