2-(2,2-Diethoxyethoxy)ethan-1-ol

Base Information

• Chemical Name: 2-(2,2-Diethoxyethoxy)ethan-1-ol
• CAS No.: 62005-55-4
• Molecular Formula: C8H18O4
• Molecular Weight: 178.229
• DSSTox Substance ID: DTXSID50541357
• Wikidata: Q82417708
• Mol file: 62005-55-4.mol

Synonyms:62005-55-4;2-(2,2-Diethoxyethoxy)ethan-1-ol;SCHEMBL8865873;DTXSID50541357

Chemical Property of 2-(2,2-Diethoxyethoxy)ethan-1-ol

Chemical Property:

• Vapor Pressure: 0.00461mmHg at 25°C
• Boiling Point: 246oC at 760 mmHg
• Flash Point: 102.6oC
• PSA: 47.92000
• Density: 1.003g/cm3
• LogP: 0.39440
• XLogP3: 0
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 8
• Exact Mass: 178.12050905
• Heavy Atom Count: 12
• Complexity: 81.1

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CCOC(COCCO)OCC

Technology Process of 2-(2,2-Diethoxyethoxy)ethan-1-ol

There total 3 articles about 2-(2,2-Diethoxyethoxy)ethan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 27.0%

ethylene glycol (107-21-1) + Bromoacetaldehyde diethyl acetal (2032-35-1) → 2-(2,2-diethoxyethoxy)ethan-1-ol (62005-55-4)

Guidance literature:

ethylene glycol; With potassium hydroxide; at 0 - 50 ℃;

Bromoacetaldehyde diethyl acetal; at 110 ℃; for 20h;

Reference yield:

C15H24O4 → 2-(2,2-diethoxyethoxy)ethan-1-ol (62005-55-4)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; at 20 ℃; for 48h; under 72402.6 Torr; Autoclave;

DOI:10.1021/jo5016135

Reference yield:

sodium methylate (124-41-4) + ethylene glycol (107-21-1) → 2-(2,2-diethoxyethoxy)ethan-1-ol (62005-55-4)

Guidance literature:

und Umsetzen des von Methanol befreiten Produkts mit Bromacetal oder Chloracetal bei 140grad im Wasserstoffstrom;

DOI:10.1021/ja01202a059

upstream raw materials:

sodium methylate

ethylene glycol

Bromoacetaldehyde diethyl acetal

Downstream raw materials:

2-(2-hydroxyethoxy)acetaldehyde

1,4-dioxane-2-ol

Refernces

• 1、 Zhang, Quanxuan,Ren, Hong,Baker, Gregory L.. "Synthesis of a library of propargylated and PEGylated α-hydroxy acids toward "clickable" polylactides via hydrolysis of cyanohydrin derivatives". . p. 9546 - 9555. Retrieved 2015/02/19.