methyl 2-amino-3-(1H-imidazol-4-yl)propanoate

Base Information

• Chemical Name: methyl 2-amino-3-(1H-imidazol-4-yl)propanoate
• CAS No.: 62013-45-0
• Molecular Formula: C7H11N3O2
• Molecular Weight: 169.18100
• Mol file: 62013-45-0.mol

Synonyms:

Chemical Property of methyl 2-amino-3-(1H-imidazol-4-yl)propanoate

Chemical Property:

• Melting Point: None °C
• Boiling Point: 368.2±27.0 °C(Predicted)
• PKA: 14.13±0.10(Predicted)
• PSA: 81.00000
• Density: 1.259±0.06 g/cm3(Predicted)
• LogP: 0.15280

Purity/Quality:

99% ^*data from raw suppliers

Methyl2-Amino-3-(1H-imidazol-4-yl)propanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 2-amino-3-(1H-imidazol-4-yl)propanoate

There total 10 articles about methyl 2-amino-3-(1H-imidazol-4-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methanol (67-56-1) + L-histidine (71-00-1,26062-48-6,90081-11-1) → L-histidine methyl ester (1499-46-3,10331-70-1,17720-12-6,62013-45-0)

Guidance literature:

With thionyl chloride; at 60 ℃; for 6h;

Reference yield:

3-(1H-Imidazol-4-yl)-2-((E)-3-oxo-propenylamino)-propionic acid methyl ester (77714-38-6) → Malondialdehyde (542-78-9) + histidine methyl ester (1499-46-3,10331-70-1,17720-12-6,62013-45-0)

Guidance literature:

With water; Rate constant; Equilibrium constant; Ambient temperature; acetate buffer (pH 4.2); enaminal hydrolysis; stereochemistry and kinetics of formation of enaminals from reactions of malondialdehydes with various amino acids;

DOI:10.1021/ja00401a020

Reference yield:

sodium; 2-{[2-(1H-imidazol-4-yl)-1-methoxycarbonyl-ethylimino]-methyl}-benzenesulfonate → sodium 2-formylbenzenesulfonate (1008-72-6) + histidine methyl ester (1499-46-3,10331-70-1,17720-12-6,62013-45-0)

Guidance literature:

In water; at 25 ℃; Equilibrium constant;

DOI:10.1002/poc.941

upstream raw materials:

3-(1H-Imidazol-4-yl)-2-((E)-3-oxo-propenylamino)-propionic acid methyl ester

3-(1H-Imidazol-4-yl)-2-((E)-2-methyl-3-oxo-propenylamino)-propionic acid methyl ester

(R)-histidine monohydrochloride monohydrate

isophorone diisocyanate

Downstream raw materials:

2,4,5-tris-benzoylamino-pent-4-enoic acid methyl ester

(S)-2-[(6-{[Benzyloxycarbonyl-(2-benzyloxycarbonylamino-ethyl)-amino]-methyl}-pyridine-2-carbonyl)-amino]-3-(3H-imidazol-4-yl)-propionic acid methyl ester

2-(3-benzyloxycarbonylamino-4,4,5,5,6,6,7,7,8,8,8-undecafluoro-octanoylamino)-3-(1H-imidazol-4-yl)-propionic acid methyl ester

2-(3-benzyloxycarbonylamino-4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-pentadecafluoro-decanoylamino)-3-(1H-imidazol-4-yl)-propionic acid methyl ester

Refernces

• 1、 -. "NOVEL PYRROLO-LACTONE AND PYRROLE COMPOUNDS INDUCING CELLULAR GLUTATHIONE RECOVERY EFFECT AGAINST REACTIVE OXYGEN SPECIES, AND METHOD FOR PREPARING THE SAME". Paragraph 0143; 0167-0171. . Retrieved 2019/05/10.
• 2、 Patil, Sachin,Belhajjame, Widad,Moosa, Basem,Khashab, Niveen M.. "Histidine–dialkoxyanthracene dyad for selective and sensitive detection of mercury ions". . p. 345 - 350. Retrieved 2017/12/26.