5,7-diphenylquinolin-8-ol

Base Information

• Chemical Name: 5,7-diphenylquinolin-8-ol
• CAS No.: 620987-09-9
• Molecular Formula: C21H15NO
• Molecular Weight: 297.356
• Mol file: 620987-09-9.mol

Synonyms:8-Quinolinol,5,7-diphenyl;5,7-diphenyl-8-hydroxy-quinoline;8-hydroxy-5,7-diphenylquinoline;

Chemical Property of 5,7-diphenylquinolin-8-ol

Chemical Property:

• Boiling Point: 452.6±40.0 °C(Predicted)
• PKA: 9.69±0.59(Predicted)
• PSA: 33.12000
• Density: 1.209±0.06 g/cm3(Predicted)
• LogP: 5.27440

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5,7-diphenylquinolin-8-ol

There total 9 articles about 5,7-diphenylquinolin-8-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

→ 8-hydroxy-5,7-diphenylquinoline (620987-09-9)

Guidance literature:

Reference yield: 66.7%

8-benzyloxy-5,7-diphenylquinoline (620987-08-8) → 8-hydroxy-5,7-diphenylquinoline (620987-09-9)

Guidance literature:

With cyclohexa-1,4-diene; palladium 10% on activated carbon; In ethanol; for 5h; Inert atmosphere; Reflux;

DOI:10.1016/j.dyepig.2013.12.007

Reference yield:

broxyquinoline (521-74-4) → 8-hydroxy-5,7-diphenylquinoline (620987-09-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 43.4 percent / KOH / ethanol; H₂O / 20 h / 100 °C

2: KOH / DAPCy / ethanol / 12 h / 50 °C

3: 40.7 percent / KI; BF₃*Et₂O / acetonitrile / 24 h / 80 °C

With potassium hydroxide; boron trifluoride diethyl etherate; potassium iodide; DAPCy; In ethanol; water; acetonitrile;

DOI:10.1039/b600912c

upstream raw materials:

8-benzyloxy-5,7-diphenylquinoline

broxyquinoline

benzyl bromide

8-benzyloxy-5,7-dibromoquinoline

Downstream raw materials:

C₆₃H₄₂AlN₃O₃

Refernces

• 1、 Al-Busafi, Saleh N.,Suliman, Fakhreldin O.,Al-Alawi, Zaid R.. "Synthesis, characterization and electronic effects investigations of new 5,7-disubstituted tris(8-quinolinolate)Al(III) complexes". . p. 138 - 144. Retrieved 2014/01/17.
• 2、 Kappaun, Stefan,Sovic, Tanja,Stelzer, Franz,Pogantsch, Alexander,Zojer, Egbert,Slugovc, Christian. "Molecular fluorescent pH-probes based on 8-hydroxyquinoline". . p. 1503 - 1511. Retrieved 2008/02/03.