2,4-Furandicarboxylic acid, 4,5-dihydro-5-oxo-3,4-diphenyl-, dimethyl ester

Base Information

• Chemical Name: 2,4-Furandicarboxylic acid, 4,5-dihydro-5-oxo-3,4-diphenyl-, dimethyl ester
• CAS No.: 62142-77-2
• Molecular Formula: C20H16O6
• Molecular Weight: 352.343
• Mol file: 62142-77-2.mol

Synonyms:

Chemical Property of 2,4-Furandicarboxylic acid, 4,5-dihydro-5-oxo-3,4-diphenyl-, dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-Furandicarboxylic acid, 4,5-dihydro-5-oxo-3,4-diphenyl-, dimethyl ester

There total 5 articles about 2,4-Furandicarboxylic acid, 4,5-dihydro-5-oxo-3,4-diphenyl-, dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

methyl 3-bromo-3-phenyl-2-oxopropanoate (77651-20-8) → dimethyl 2-oxo-3,4-diphenyl-2,3-dihydrofuran-3,5-dicarboxylate (62142-77-2)

Guidance literature:

With silica gel; copper dichloride; In chlorobenzene; at 128 - 130 ℃; for 23h;

Reference yield: 64.0%

methyl 3-phenyl-3-chloro-2-ketopropionate (32803-73-9) → dimethyl 2-oxo-3,4-diphenyl-2,3-dihydrofuran-3,5-dicarboxylate (62142-77-2)

Guidance literature:

methyl 3-phenyl-3-chloro-2-ketopropionate; With potassium hydroxide; In water; toluene;

at 250 - 270 ℃; for 2h; Mechanism;

DOI:10.1007/s11172-015-1239-1

Reference yield:

(erythro-threo)-methyl-2-cyano-3-fluoro-2-hydroxy-3-phenylpropanoate (90179-18-3) → dimethyl 2-oxo-3,4-diphenyl-2,3-dihydrofuran-3,5-dicarboxylate (62142-77-2) + methyl 3-phenyl-3-chloro-2-ketopropionate (32803-73-9) + benzaldehyde (100-52-7)

Guidance literature:

With silica gel; copper dichloride; In chlorobenzene; at 130 ℃; for 23h; var. reag.: silica-gel-supported CuCl₂, CuBr₂, CoCl₂, ZnBr₂, FeCl₃, and only CuCl₂, CoCl₂, CuBr₂, ZnBr₂; var. solv.: MeCN, benzene, var.time and temp.;

upstream raw materials:

(erythro-threo)-methyl-2-cyano-3-fluoro-2-hydroxy-3-phenylpropanoate

methyl 3-bromo-3-phenyl-2-oxopropanoate

methyl 3-phenyl-3-chloro-2-ketopropionate

Refernces

• 1、 Brine, N.,Foucaud, A.. "Regioselective ring opening of 3-aryl-2-cyano-2-(methoxycarbonyl)oxiranes with metal halides and silica-gel-supported metal halides. Synthesis of substituted but-3-en-4-olides.". . p. 620 - 624. Retrieved 2007/10/02.