4-(5-Formylfuran-2-yl)benzenesulfonamide

Base Information

• Chemical Name: 4-(5-Formylfuran-2-yl)benzenesulfonamide
• CAS No.: 21821-40-9
• Molecular Formula: C11H9NO4S
• Molecular Weight: 251.263
• Hs Code.: 2935009090
• DSSTox Substance ID: DTXSID30350005
• Nikkaji Number: J1.726.155J
• Wikidata: Q82125677
• ChEMBL ID: CHEMBL1383325
• Mol file: 21821-40-9.mol

Synonyms:4-(5-formylfuran-2-yl)benzenesulfonamide;21821-40-9;4-(5-Formyl-2-Furyl)Benzene-1-Sulfonamide;4-(5-formyl-2-furyl)benzenesulfonamide;4-(5-formylfuran-2-yl)benzene-1-sulfonamide;4-(5-formyl-2-furanyl)benzenesulfonamide;4-(5-methanoylfuran-2-yl)benzenesulfonamide;Cambridge id 5324768;Oprea1_220194;Oprea1_714642;MLS000713259;SCHEMBL706809;CHEMBL1383325;DTXSID30350005;CTFUCNXKRYTIQE-UHFFFAOYSA-N;HMS2625N14;BBL015268;STK508294;AKOS000267261;PS-4475;SB61489;SMR000272740;4-(5-Formylfur-2-yl)benzene-1-sulfonamide;4-(5-Formylfur-2-yl)benzene-1-sulphonamide;BB 0246609;CS-0221014;FT-0638152;EN300-08148;A815642;A815683;Z56899029;4-(5-formyl-2-furyl)benzene-1-sulfonamide, AldrichCPR;F0008-0159

Chemical Property of 4-(5-Formylfuran-2-yl)benzenesulfonamide

Chemical Property:

• Vapor Pressure: 7.26E-10mmHg at 25°C
• Melting Point: 199 °C
• Refractive Index: 1.605
• Boiling Point: 493.1 °C at 760 mmHg
• Flash Point: 252 °C
• PSA: 98.75000
• Density: 1.41 g/cm³
• LogP: 3.18760
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 251.02522894
• Heavy Atom Count: 17
• Complexity: 367

Purity/Quality:

98%min ^*data from raw suppliers

4-(5-Formylfuran-2-yl)benzenesulfonamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC=C1C2=CC=C(O2)C=O)S(=O)(=O)N

Technology Process of 4-(5-Formylfuran-2-yl)benzenesulfonamide

There total 4 articles about 4-(5-Formylfuran-2-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

furfural (98-01-1) + 4-(aminosulphonyl)benzenediazonium chloride (35282-78-1) → 5-(4-aminosulfonylphenyl)furan-2-carbaldehyde (21821-40-9)

Guidance literature:

With copper(II) choride dihydrate; In acetone; at 0 - 30 ℃;

DOI:10.1134/S107042801406013X

Reference yield:

5-formylfurane-2-boronic acid (27329-70-0) + 4-bromo-benzenesulfonic acid amide (701-34-8) → 5-(4-aminosulfonylphenyl)furan-2-carbaldehyde (21821-40-9)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In water; acetonitrile; at 80 ℃; for 2h;

Reference yield:

5-bromo-2-furancarboxaldehyde (1899-24-7) + 4-sulfamoylphenylboronic acid (613660-87-0) → 5-(4-aminosulfonylphenyl)furan-2-carbaldehyde (21821-40-9)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; toluene; for 5h; Heating;

DOI:10.1016/S0960-894X(03)00353-6

upstream raw materials:

5-bromo-2-furancarboxaldehyde

4-sulfamoylphenylboronic acid

furfural

4-(aminosulphonyl)benzenediazonium chloride

Downstream raw materials:

4-{5-[(E)-(naphthalen-2-ylimino)methyl]furan-2-yl}benzenesulfonamide

4-[5-(9,9-dimethyl-11-oxo-7,8,9,10,11,12-hexahydrobenzo[a]acridin-12-yl)furan-2-yl]benzenesulfonamide

methyl 4-(3,5-dioxo-4-((5-(4-sulfamoylphenyl)furan-2-yl)methylene)pyrazolidin-1-yl)benzoate

C₂₂H₁₇N₃O₆S

Refernces

• 1、 Kozlov,Zhikharko,Lytvyn,Gorak,Skakovskii,Baranovskii,Basalaeva,Obushak. "Synthesis of 12-hetaryl-9,9-dimethyl-7,8,9,10-tetrahydrobenzo[a]acridin- 11(12H)-ones". . p. 833 - 839. Retrieved 2014/08/18.
• 2、 Pfefferkorn, Jeffrey A.,Greene, Meredith L.,Nugent, Richard A.,Gross, Rebecca J.,Mitchell, Mark A.,Finzel, Barry C.,Harris, Melissa S.,Wells, Peter A.,Shelly, John A.,Anstadt, Robert A.,Kilkuskie, Robert E.,Kopta, Laurice A.,Schwende, Francis J.. "Inhibitors of HCV NS5B polymerase. Part 1: Evaluation of the southern region of (2Z)-2-(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid". . p. 2481 - 2486. Retrieved 2007/10/03.