2-fluorobenzyl azide

Base Information

• Chemical Name: 2-fluorobenzyl azide
• CAS No.: 62284-30-4
• Molecular Formula: C7H6FN3
• Molecular Weight: 151.14100
• Hs Code.: 2929909090
• Mol file: 62284-30-4.mol

Synonyms:Benzene,1-(azidomethyl)-2-fluoro;

Chemical Property of 2-fluorobenzyl azide

Chemical Property:

• Flash Point: -30℃
• PSA: 49.75000
• LogP: 2.08876
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(Azidomethyl)-2-fluorobenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s): 8403230
• Hazard Codes: F,Xi
• Statements: 11-38
• Safety Statements: 16

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-fluorobenzyl azide

There total 18 articles about 2-fluorobenzyl azide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

o-fluorobenzyl bromide (446-48-0) → 2-fluorobenzyl azide (62284-30-4)

Guidance literature:

With sodium azide; In N,N-dimethyl-formamide; at 20 - 80 ℃; for 4h;

DOI:10.1002/cmdc.201402374

Reference yield: 70.0%

C8H7F4NO2S (1159505-61-9) → 2-fluorobenzyl azide (62284-30-4)

Guidance literature:

C₈H₇F₄NO₂S; With trifluoromethylsulfonic anhydride; sodium hydride; In dichloromethane; at -78 - 0 ℃; for 2h;

With sodium azide; In N,N,N,N,N,N-hexamethylphosphoric triamide; at 20 ℃; for 8h;

Reference yield: 66.0%

→ 2-fluorobenzyl azide (62284-30-4)

Guidance literature:

With sodium azide; In water; at 65 - 75 ℃; for 5h;

upstream raw materials:

C₈H₇F₄NO₂S

o-fluorobenzyl bromide

benzylamine

N-benzyl-1,1,1-trifluoromethanesulfonamide

Downstream raw materials:

2-fluorobenzylamine

Refernces

• 1、 Rezaei, Elham Babazadeh,Abedinifar, Fahimeh,Azizian, Homa,Montazer, Mohammad Nazari,Asadi, Mehdi,Hosseini, Samanesadat,Sepehri, Saghi,Mohammadi-Khanaposhtani, Maryam,Biglar, Mahmood,Larijani, Bagher,Amanlou, Massoud,Mahdavi, Mohammad. "Design, synthesis, and evaluation of metronidazole-1,2,3-triazole derivatives as potent urease inhibitors". . p. 4217 - 4226. Retrieved 2021/04/26.
• 2、 Baheej, M. A. A.,Choudhary, M. Iqbal,Haniffa, Haroon M.,Iqbal, Shazia,Rizvi, Fazila,Siddiqui, Hina,Ullah, Saeed,Wahab, Atia-tul. "Synthesis of 1,2,3,triazole modified analogues of hydrochlorothiazide via click chemistry approach and in-vitro α-glucosidase enzyme inhibition studies". . . Retrieved 2021/10/07.