6,7-dihydro-4H-pyrazolo[5,1-c][1,4]thiazine-2-carbaldehyde dioxide

Base Information

• Chemical Name: 6,7-dihydro-4H-pyrazolo[5,1-c][1,4]thiazine-2-carbaldehyde dioxide
• CAS No.: 623565-07-1
• Molecular Formula: C7H8N2O3S
• Molecular Weight: 200.218
• Hs Code.: 2934999090
• Mol file: 623565-07-1.mol

Synonyms:6,7-Dihydro-4H-pyrazolo[5,1-c][1,4]thiazine-2-carbaldehyde 5,5-dioxide;6,7-dihydro-4H-pyrazolo[5,1-c][1,4]thiazine-2-carbaldehydedioxide;QC-9787;

Chemical Property of 6,7-dihydro-4H-pyrazolo[5,1-c][1,4]thiazine-2-carbaldehyde dioxide

Chemical Property:

• PSA: 77.41000
• LogP: 0.70480
• Storage Temp.: 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

6,7-Dihydro-4H-pyrazolo[5,1-c][1,4]thiazine-2-carbaldehyde5,5-dioxide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6,7-dihydro-4H-pyrazolo[5,1-c][1,4]thiazine-2-carbaldehyde dioxide

There total 3 articles about 6,7-dihydro-4H-pyrazolo[5,1-c][1,4]thiazine-2-carbaldehyde dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

6,7-dihydro-4H-pyrazolo[5,1-c][1,4]thiazine-2-carbaldehyde (623564-62-5) → 5,5-dioxo-4,5,6,7-tetrahydro-5λ6-pyrazolo[5,1-c][1,4]thiazine-2-carbaldehyde (623565-07-1)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 18h;

DOI:10.1021/jm060021p

Reference yield:

(6,7-dihydro-4H-pyrazolo[5,1-c] [1,4]thiazin-2-yl)methanol (623564-61-4) → 5,5-dioxo-4,5,6,7-tetrahydro-5λ6-pyrazolo[5,1-c][1,4]thiazine-2-carbaldehyde (623565-07-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.78 g / MnO₂ / CHCl₃ / 1 h / Heating

2: 89 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 18 h / 20 °C

With manganese(IV) oxide; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; chloroform;

DOI:10.1021/jm060021p

Reference yield:

6,7-dihydro-4H-pyrazolo[5,1-c][1,4]thiazine-2-carboxylic acid ethyl ester (623564-59-0) → 5,5-dioxo-4,5,6,7-tetrahydro-5λ6-pyrazolo[5,1-c][1,4]thiazine-2-carbaldehyde (623565-07-1)

Guidance literature:

Multi-step reaction with 3 steps

1: LiBH₄ / methanol; tetrahydrofuran / 3 h / 20 - 40 °C

2: 1.78 g / MnO₂ / CHCl₃ / 1 h / Heating

3: 89 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 18 h / 20 °C

With manganese(IV) oxide; lithium borohydride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; dichloromethane; chloroform;

DOI:10.1021/jm060021p

upstream raw materials:

6,7-dihydro-4H-pyrazolo[5,1-c][1,4]thiazine-2-carbaldehyde

(6,7-dihydro-4H-pyrazolo[5,1-c] [1,4]thiazin-2-yl)methanol

6,7-dihydro-4H-pyrazolo[5,1-c][1,4]thiazine-2-carboxylic acid ethyl ester

Downstream raw materials:

(5R,6RS)-6-[(RS)-acetoxy-(5,5-dioxo-4,5,6,7-tetrahydro-5λ⁶-pyrazolo[5,1-c][1,4]thiazin-2-yl)methyl]-6-bromo-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid 4-nitrobenzyl ester

Refernces

• 1、 -. "Bicyclic 6-alkylidene-penems as class-D beta-lactamases inhibitors". Page/Page column 31. . Retrieved 2010/11/25.