3-Oxo-2-(2-phenylhydrazono)butanoic acid ethyl ester

Base Information

• Chemical Name: 3-Oxo-2-(2-phenylhydrazono)butanoic acid ethyl ester
• CAS No.: 10475-63-5
• Molecular Formula: C12H14 N2 O3
• Molecular Weight: 234.255
• Mol file: 10475-63-5.mol

Synonyms:Butanoicacid, 3-oxo-2-(phenylhydrazono)-, ethyl ester (9CI); Butyric acid, 2,3-dioxo-,ethyl ester, 2-(phenylhydrazone) (6CI,7CI,8CI); Ethyl 2,3-dioxobutanoate2-phenylhydrazone; Ethyl 3-oxo-2-(phenylhydrazono)butanoate

Chemical Property of 3-Oxo-2-(2-phenylhydrazono)butanoic acid ethyl ester

Chemical Property:

• Vapor Pressure: 9.06E-05mmHg at 25°C
• Boiling Point: 339.6°Cat760mmHg
• Flash Point: 159.2°C
• PSA: 67.76000
• Density: 1.13g/cm³
• LogP: 1.67960

Purity/Quality:

98%,99%, ^*data from raw suppliers

Ethyl(E)-3-Oxo-2-(2-phenylhydrazono)butanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Oxo-2-(2-phenylhydrazono)butanoic acid ethyl ester

There total 20 articles about 3-Oxo-2-(2-phenylhydrazono)butanoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

ethyl acetoacetate (141-97-9) + aniline (62-53-3) → 3-oxo-2-(phenylhydrazono)butyric acid ethyl ester (10475-63-5)

Guidance literature:

aniline; With hydrogenchloride; sodium nitrite; In water; at -5 - 20 ℃; for 0.5h;

ethyl acetoacetate; With sodium acetate; In ethanol; water; at 0 ℃; for 2h;

Reference yield: 81.0%

ethyl acetoacetate (141-97-9) + aniline (62-53-3) → 3-oxo-2-(phenylhydrazono)butyric acid ethyl ester (10475-63-5)

Guidance literature:

aniline; With sodium nitrite; for 0.0833333h;

In water; for 0.166667h;

ethyl acetoacetate; phenyl diazonium silica sulfate nanocomposite; With potassium carbonate; In water; at 20 ℃; for 0.166667h;

DOI:10.1016/j.dyepig.2021.109544

Reference yield: 80.0%

benzenediazonium tetrafluoroborate (369-57-3) + ethyl acetoacetate (141-97-9) → 3-oxo-2-(phenylhydrazono)butyric acid ethyl ester (10475-63-5)

Guidance literature:

With sodium acetate; silica gel; In neat (no solvent); at 20 ℃; for 0.333333h; Milling;

DOI:10.2174/1570178611999140404111411

upstream raw materials:

benzenediazonium

ethanol

sodium ethanolate

ethyl acetoacetate

Downstream raw materials:

3-methyl-1-phenylpyrazole-4,5-dione 4-phenylhydrazone

3-oxo-2-phenylhydrazono-butyric acid methylamide

1-(4,6-dimethylpyrimidin-2-yl)-3-methyl-4-phenylhydrazono-2-pyrazoline-5-one

3-Methyl-4-(phenylhydrazono)-1-phthalazyl-2-pyrazolin-5-one

Refernces

• 1、 Vedenyanin, A. A.,Murina, I. P.,Kuznetsova, T. I.,Klabunovskii, E. I.. "PREPARATION OF AN ALLO-THREONINE DERIVATIVE BY THE CATALYTIC HYDROGENATION OF ETHYL α-ACETYLAMINO-β-KETOBUTYRATE ON MODIFIED CATALYSTS". . p. 2369 - 2371. Retrieved 1986.
• 2、 Kotali, Antigoni,Maniadaki, Anna,Kotali, Elvira,Harris, Philip A.,Rózycka-Soko?owska, Ewa,Ba?czewski, Piotr,Joule, John A.. "Synthesis of Bicyclic Boron Heterocycles Containing [1,3,4,2]Oxadiazaborole and [1,3,2]Oxazaborine". . p. 4117 - 4125. Retrieved 2016.
• 3、 Chu, Bizhu,Jiang, Yuyang,Li, Qinyuan,Liu, Zijian,Luo, Jingyi,Shi, Zhichao,Xin, Qilei,Ye, Lizhen,Zhan, Feng,Zhang, Xun,Zhu, Qingyun. "Design, synthesis and anti-tumor evaluation of 1,2,4-triazol-3-one derivatives and pyridazinone derivatives as novel CXCR2 antagonists". . . Retrieved 2021/09/20.