5,6-DIMETHOXY-1,3-DIHYDRO-INDOL-2-ONE

Base Information

• Chemical Name: 5,6-DIMETHOXY-1,3-DIHYDRO-INDOL-2-ONE
• CAS No.: 6286-64-2
• Molecular Formula: C10H11NO3
• Molecular Weight: 193.202
• Mol file: 6286-64-2.mol

Synonyms:5,6-dimethoxy-1,3-dihydro-indol-2-one;5,6-dimethoxy-2-oxindole;5,6-dimethoxyindolin-2-one;5,6-Dimethoxy-indolin-2-on;5,6-dimethoxy-2-indolinone;5,6-dimethoxyoxindole;

Chemical Property of 5,6-DIMETHOXY-1,3-DIHYDRO-INDOL-2-ONE

Chemical Property:

• Vapor Pressure: 1.21E-05mmHg at 25°C
• Melting Point: 204-205 °C
• Boiling Point: 369.2°Cat760mmHg
• PKA: 13.02±0.20(Predicted)
• Flash Point: 177.1°C
• PSA: 47.56000
• Density: 1.214g/cm³
• LogP: 1.33640

Purity/Quality:

99% ^*data from raw suppliers

5,6-dimethoxy-2,3-dihydro-1H-indol-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5,6-DIMETHOXY-1,3-DIHYDRO-INDOL-2-ONE

There total 16 articles about 5,6-DIMETHOXY-1,3-DIHYDRO-INDOL-2-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-(3,4-dimethoxybenzyl)-1,4,2-dioxazol-5-one → 5,6-dimethoxy-2-indolinone (6286-64-2)

Guidance literature:

With C₁₈H₂₄ClIrN₃⁽¹⁺⁾*Cl^(1-); sodium tetrakis[(3,5-di-trifluoromethyl)phenyl]borate; In dichloromethane; at 40 ℃; for 4h;

DOI:10.1021/acs.joc.0c00157

Reference yield: 90.9%

(4,5-dimethoxy-2-nitrophenyl)acetic acid (73357-18-3) → 5,6-dimethoxy-2-indolinone (6286-64-2)

Guidance literature:

With iron; acetic acid; at 20 ℃; for 1h; Heating / reflux;

Reference yield: 88.0%

1,5,6-TRIMETHOXYINDOLIN-2-ONE (121989-31-9) → 5,6-dimethoxy-2-indolinone (6286-64-2)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol;

DOI:10.1021/jo00275a027

upstream raw materials:

(4,5-dimethoxy-2-nitrophenyl)acetic acid

(2-amino-4,5-dimethoxy-phenyl)-acetic acid

(2-amino-4,5-dimethoxy-phenyl)-acetic acid amide

(4,5-dimethoxy-2-nitro-phenyl)-acetic acid amide

Downstream raw materials:

propionic acid

oxalic acid

acetic acid

Glyoxilic acid

Refernces

• 1、 -. "NURR1 RECEPTOR MODULATORS". . . Retrieved 2020/09/08.
• 2、 -. "METHOD FOR PRODUCING LACTAM COMPOUND, AND LACTAM COMPOUND PRODUCED THEREBY". Paragraph 0160-0161; 0165. . Retrieved 2020/11/30.