ACETIC ACID METHYLTHIOMETHYL ESTER

Base Information

• Chemical Name: ACETIC ACID METHYLTHIOMETHYL ESTER
• CAS No.: 16437-69-7
• Molecular Formula: C4H8 O2 S
• Molecular Weight: 120.172
• Hs Code.: 29159000
• Mol file: 16437-69-7.mol

Synonyms:Methanol,(methylthio)-, acetate (7CI,8CI,9CI); Methylthiomethyl acetate

Chemical Property of ACETIC ACID METHYLTHIOMETHYL ESTER

Chemical Property:

• Vapor Pressure: 3.03mmHg at 25°C
• Refractive Index: 1.4547
• Boiling Point: 155.4°Cat760mmHg
• Flash Point: 54.2°C
• PSA: 51.60000
• Density: 1.072g/cm³
• LogP: 0.87000

Purity/Quality:

98%,99%, ^*data from raw suppliers

Methylthiomethyl Acetate ^*data from reagent suppliers

Safty Information:

• Statements: 10-36/37/38
• Safety Statements: 16-37-26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ACETIC ACID METHYLTHIOMETHYL ESTER

There total 15 articles about ACETIC ACID METHYLTHIOMETHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

acetic anhydride (108-24-7) + dimethyl sulfoxide (67-68-5,8070-53-9) → (methylthio)methyl acetate (16437-69-7)

Guidance literature:

at 100 ℃; for 7h;

DOI:10.1023/B:RUJO.0000013129.67738.9b

Reference yield: 95.0%

acetic acid (64-19-7,77671-22-8) + dimethyl sulfoxide (67-68-5,8070-53-9) → (methylthio)methyl acetate (16437-69-7)

Guidance literature:

With t-butyl bromide; sodium hydrogencarbonate; at 25 - 30 ℃; for 24h;

DOI:10.1039/P19810002737

Reference yield: 86.0%

dimethylsulfide (75-18-3) + acetic anhydride (108-24-7) → (methylthio)methyl acetate (16437-69-7)

Guidance literature:

In benzene; for 5h; Reflux;

DOI:10.1016/j.tet.2009.10.096

upstream raw materials:

Chloromethyl acetate

sodium thiomethoxide

chloroform

acetic anhydride

Downstream raw materials:

Dimethyl-acetoxymethyl-sulfonium

2,4-dithiapentane

(4-methoxybenzyl)methylsulfide

p-methoxybenzyl acetate

Refernces

• 1、 Oae et al.. "". . p. 1783,1787. Retrieved 1963.
• 2、 Kise,H. et al.. "-". . p. 4839 - 4842. Retrieved 1971.
• 3、 Li, Hui,Liu, Haiping,Liu, Yufeng,Cao, Zhongzhong,Su, Miaodong,Fu, Meiqiang,Luo, Weiping,Liu, Qiang,Guo, Cancheng. "Efficient Synthesis of 3,6-Dihydro-2H-pyrans via [3+2+1] Annulation Based on the Heteroatom-free Tri-atom Donor". supporting information. p. 5392 - 5399. Retrieved 2019/11/11.
• 4、 Jones, J.H.,Thomas, D.W.,Thomas, R.M.,Wood, M.E.. "t-BUTYL CHLOROMETHYL ETHER". . p. 1607 - 1610. Retrieved 2007/10/02.