4-((2-Aminoethoxy)ethyl)morpholine

Base Information

• Chemical Name: 4-((2-Aminoethoxy)ethyl)morpholine
• CAS No.: 20207-13-0
• Molecular Formula: C8H18N2O2
• Molecular Weight: 174.243
• Hs Code.: 2934999090
• European Community (EC) Number: 243-595-4
• UNII: 3KL5GGM6DE
• DSSTox Substance ID: DTXSID20174055
• Nikkaji Number: J280.482D
• Wikidata: Q83044106
• Mol file: 20207-13-0.mol

Synonyms:20207-13-0;4-((2-Aminoethoxy)ethyl)morpholine;2-(2-Morpholin-4-yl-ethoxy)-ethylamine;2-(2-Morpholinoethoxy)ethanamine;2-(2-morpholin-4-ylethoxy)ethanamine;EINECS 243-595-4;3KL5GGM6DE;2-(2-Morpholin-4-yl)ethoxy)ethylamine;4-[(2-AMINOETHOXY)ETHYL]MORPHOLINE;MFCD11934676;Ethanamine, 2-(2-(4-morpholinyl)ethoxy)-;Ethanamine, 2-[2-(4-morpholinyl)ethoxy]-;2-[2-(morpholin-4-yl)ethoxy]ethan-1-amine;UNII-3KL5GGM6DE;SCHEMBL2635588;DTXSID20174055;AKOS011628502;2-(2-morpholin-4-yl-ethoxy)ethylamine;CS-0214626;EN300-1850263

Chemical Property of 4-((2-Aminoethoxy)ethyl)morpholine

Chemical Property:

• Vapor Pressure: 0.0084mmHg at 25°C
• Boiling Point: 266.9°Cat760mmHg
• Flash Point: 115.2°C
• PSA: 47.72000
• Density: 1.029g/cm³
• LogP: -0.06790
• XLogP3: -1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 174.136827821
• Heavy Atom Count: 12
• Complexity: 105

Purity/Quality:

99% ^*data from raw suppliers

2-[2-(Morpholin-4-yl)ethoxy]ethan-1-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1COCCN1CCOCCN
• Uses: 2-[2-(Morpholin-4-yl)ethoxy]ethan-1-amine can be used as RET kinase inhibitors.

Technology Process of 4-((2-Aminoethoxy)ethyl)morpholine

There total 3 articles about 4-((2-Aminoethoxy)ethyl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[2-(2-Azido-ethoxy)-ethyl]-morpholine (162733-11-1) → 2-<2-(4-morpholino)ethoxy>ethylamine (20207-13-0)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 18h; under 2068.6 Torr; Ambient temperature;

DOI:10.1021/jm00041a006

Reference yield:

4-(2(2-hydroxyethoxy)ethyl)-morpholine (3603-45-0,53404-03-8) → 2-<2-(4-morpholino)ethoxy>ethylamine (20207-13-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 46 percent / ZnN₆*2Py, DIAD, Ph₃P / toluene / Ambient temperature

2: H₂ / 10percent Pd/C / ethanol / 18 h / 2068.6 Torr / Ambient temperature

With Zn(N₃)2/bis-pyridine complex; di-isopropyl azodicarboxylate; hydrogen; triphenylphosphine; palladium on activated charcoal; In ethanol; toluene;

DOI:10.1021/jm00041a006

Reference yield:

→ 2-<2-(4-morpholino)ethoxy>ethylamine (20207-13-0)

Guidance literature:

upstream raw materials:

4-[2-(2-Azido-ethoxy)-ethyl]-morpholine

4-(2(2-hydroxyethoxy)ethyl)-morpholine

Refernces

• 1、 -. "Amine bisulfites". . . Retrieved 2008/06/13.