3-broMo-5-Methanesulfonylaniline

Base Information

• Chemical Name: 3-broMo-5-Methanesulfonylaniline
• CAS No.: 62606-00-2
• Molecular Formula: C7H8BrNO2S
• Molecular Weight: 250.116
• Hs Code.: 2921420090
• Mol file: 62606-00-2.mol

Synonyms:3-bromo-5-methylsulfonylaniline;

Chemical Property of 3-broMo-5-Methanesulfonylaniline

Chemical Property:

• Boiling Point: 452.9±45.0 °C(Predicted)
• PKA: 1.58±0.10(Predicted)
• PSA: 68.54000
• Density: 1.671±0.06 g/cm3(Predicted)
• LogP: 3.09680
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

99% ^*data from raw suppliers

3-Bromo-5-(methylsulfonyl)aniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Bromo-5-(methylsulfonyl)aniline is used in the preparation of WDR5-?MYC inhibitors.

Technology Process of 3-broMo-5-Methanesulfonylaniline

There total 2 articles about 3-broMo-5-Methanesulfonylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

3-Bromo-5-iodoaniline (31948-87-5) + sodium methansulfinate (20277-69-4) → 3-bromo-5-(methylsulfonyl)aniline (62606-00-2) + 3-iodo-5-(methylsulfonyl)aniline (62606-01-3)

Guidance literature:

With copper(l) iodide; L-proline; sodium hydroxide; In dimethyl sulfoxide; at 60 ℃;

Reference yield: 40.0%

1-bromo-3-(methylsulfonyl)-5-nitrobenzene (62606-15-9) → 3-bromo-5-(methylsulfonyl)aniline (62606-00-2)

Guidance literature:

With hydrogen; nickel; In tetrahydrofuran; under 750.075 Torr;

Reference yield:

2,4,6-trinitrochlorobenzene (88-88-0) + 3-bromo-5-(methylsulfonyl)aniline (62606-00-2) → (3-Bromo-5-methanesulfonyl-phenyl)-(2,4,6-trinitro-phenyl)-amine (62606-07-9)

Guidance literature:

In acetonitrile; at 25 ℃; Kinetics;

DOI:10.1039/P29770000014

upstream raw materials:

1-bromo-3-(methylsulfonyl)-5-nitrobenzene

3-Bromo-5-iodoaniline

sodium methansulfinate

Downstream raw materials:

(3-Bromo-5-methanesulfonyl-phenyl)-(2,4,6-trinitro-phenyl)-amine

Refernces

• 1、 -. "Pteridinone derivatives as PI3-kinases inhibitors". Page/Page column 13. . Retrieved 2008/12/07.