N-Dodecyl-4-methylaniline

Base Information

• Chemical Name: N-Dodecyl-4-methylaniline
• CAS No.: 62641-34-3
• Molecular Formula: C19H33N
• Molecular Weight: 275.478
• DSSTox Substance ID: DTXSID00573704
• Nikkaji Number: J1.660.922F
• Wikidata: Q82462506
• Mol file: 62641-34-3.mol

Synonyms:N-Dodecyl-4-methylaniline;62641-34-3;SCHEMBL3682494;DTXSID00573704;AKOS012795402

Chemical Property of N-Dodecyl-4-methylaniline

Chemical Property:

• XLogP3: 7.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 12
• Exact Mass: 275.261300057
• Heavy Atom Count: 20
• Complexity: 194

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCCCCCCCCCNC1=CC=C(C=C1)C

Technology Process of N-Dodecyl-4-methylaniline

There total 12 articles about N-Dodecyl-4-methylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

p-cresol (106-44-5) + n-Dodecylamine (124-22-1) → N-dodecyl-4-methylbenzenamine (62641-34-3)

Guidance literature:

With [(η⁵-C₅(CH₃)₄^{3,5-bis(trifluoromethyl)benzene})RhCl₂]₂; sodium carbonate; In n-heptane; at 140 ℃; for 36h; Sealed tube; Inert atmosphere; Molecular sieve;

DOI:10.1021/jacs.1c12622

Reference yield: 84.0%

1-dodecyl alcohol (112-53-8) + p-toluidine (106-49-0,12221-03-3) → N-dodecyl-4-methylbenzenamine (62641-34-3)

Guidance literature:

With NiCuFeO(x); In 5,5-dimethyl-1,3-cyclohexadiene; for 24h; Inert atmosphere; Sealed tube; Reflux;

DOI:10.1002/chem.201203417

Reference yield: 78.0%

1-dodecyne (765-03-7) + p-toluidine (106-49-0,12221-03-3) → N-dodecyl-4-methylbenzenamine (62641-34-3) + (1-methyl-undecyl)-p-tolyl-amine

Guidance literature:

1-dodecyne; p-toluidine; bis(indenyl)dimethyl-titanium; In toluene; at 75 ℃; for 8h;

With sodium cyanoborohydride; zinc(II) chloride; In methanol; toluene; at 25 ℃; for 20h;

DOI:10.1002/chem.200305771

upstream raw materials:

1-dodecyl alcohol

p-toluidine

1-chlorododecane

1-dodecyne

Downstream raw materials:

N-allyl-N-dodecyl-4-methylbenzenamine

Refernces

• 1、 Nuzhdin, Alexey L.,Artiukha, Ekaterina A.,Bukhtiyarova, Galina A.,Derevyannikova, Elizaveta A.,Bukhtiyarov, Valerii I.. "Synthesis of secondary amines by reductive amination of aldehydes with nitroarenes over supported copper catalysts in a flow reactor". . p. 108 - 113. Retrieved 2017/09/15.
• 2、 Cui, Xinjiang,Dai, Xingchao,Deng, Youquan,Shi, Feng. "Development of a general non-noble metal catalyst for the benign amination of alcohols with amines and ammonia". supporting information. p. 3665 - 3675. Retrieved 2013/03/29.