Diphenyl-2-pyridylmethane

Base Information

• Chemical Name: Diphenyl-2-pyridylmethane
• CAS No.: 3678-70-4
• Molecular Formula: C18H15N
• Molecular Weight: 245.324
• Hs Code.: 29333999
• European Community (EC) Number: 222-953-3
• NSC Number: 60653
• UNII: SZE5F94WJH
• DSSTox Substance ID: DTXSID10190244
• Nikkaji Number: J149.745F
• Wikipedia: Diphenyl-2-pyridylmethane
• Wikidata: Q5279735
• Pharos Ligand ID: 8GUV7NVL1XS2
• ChEMBL ID: CHEMBL347772
• Mol file: 3678-70-4.mol

Synonyms:Diphenyl-2-pyridylmethane;2-Benzhydrylpyridine;3678-70-4;Pyridine, 2-(diphenylmethyl)-;2-(diphenylmethyl)pyridine;2-Benzhydryl-pyridine;SZE5F94WJH;DIPHENYL-2-PYRIDYLMETHANE, 98;CHEMBL347772;EINECS 222-953-3;NSC 60653;NSC-60653;NSC60653;2-Benzhydrylpyridine #;UNII-SZE5F94WJH;SCHEMBL3290275;DTXSID10190244;BDBM50123262;STL371973;AKOS016033753;NCI60_004668;FT-0625247;AO-801/41077383;Q5279735

Chemical Property of Diphenyl-2-pyridylmethane

Chemical Property:

• Appearance/Colour: light yellow-orange cryst. powder and crystal
• Vapor Pressure: 4.81E-05mmHg at 25°C
• Melting Point: 54-61°C
• Refractive Index: 1.607
• Boiling Point: 359.8 °C at 760 mmHg
• PKA: 4.81±0.10(Predicted)
• Flash Point: 153.6 °C
• PSA: 12.89000
• Density: 1.085 g/cm³
• LogP: 4.26180
• XLogP3: 4.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 245.120449483
• Heavy Atom Count: 19
• Complexity: 232

Purity/Quality:

98%min ^*data from raw suppliers

DIPHENYL-2-PYRIDYLMETHANE 98.00% ^*data from reagent suppliers

Safty Information:

• Safety Statements: S24/25:Avoid contact with skin and eyes.

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)C3=CC=CC=N3

Technology Process of Diphenyl-2-pyridylmethane

There total 25 articles about Diphenyl-2-pyridylmethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-Benzylpyridine (101-82-6) + bromobenzene (108-86-1,52753-63-6) → Diphenyl-2-pyridylmethan (3678-70-4)

Guidance literature:

With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; sodium hexamethyldisilazane; nixantphos; at 20 ℃; for 16h; Reagent/catalyst; Catalytic behavior;

DOI:10.1039/c5sc03704b

Reference yield: 92.0%

2-Benzylpyridine (101-82-6) + chlorobenzene (108-90-7) → Diphenyl-2-pyridylmethan (3678-70-4)

Guidance literature:

With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; sodium hexamethyldisilazane; nixantphos; at 50 ℃; for 16h; Temperature; Catalytic behavior;

DOI:10.1039/c5sc03704b

Reference yield: 89.0%

3-phenyl-[1,2,3]triazolo[1,5-a]pyridine (832-81-5) + phenylboronic acid (98-80-6) → Diphenyl-2-pyridylmethan (3678-70-4)

Guidance literature:

With potassium carbonate; In benzene; at 20 ℃; for 16h; Reagent/catalyst; Solvent; Wavelength; UV-irradiation;

DOI:10.1039/c9sc02448d

upstream raw materials:

α-picoline

chlorobenzene

diphenyl(2-pyridyl)methanol

2-pyridynyldiphenylacetonitrile

Downstream raw materials:

2-[(Dichloro-methyl-silanyl)-diphenyl-methyl]-pyridine

2-(Dichlorosilanyl-diphenyl-methyl)-pyridine

lithium diphenyl-2-pyridylmethanethiolate

2-(2-chloro-1,1-diphenylethyl)pyridine

Refernces

• 1、 Dardir, Amira H.,Casademont-Reig, Irene,Balcells, David,Ellefsen, Jonathan D.,Espinosa, Matthew R.,Hazari, Nilay,Smith, Nicholas E.. "Synthesis of Triarylmethanes via Palladium-Catalyzed Suzuki-Miyaura Reactions of Diarylmethyl Esters". supporting information. p. 2332 - 2344. Retrieved 2021/06/28.
• 2、 Thongpaen, Jompol,Schmid, Thibault E.,Toupet, Loic,Dorcet, Vincent,Mauduit, Marc,Baslé, Olivier. "Directed: Ortho C-H borylation catalyzed using Cp?Rh(iii)-NHC complexes". supporting information. p. 8202 - 8205. Retrieved 2018/07/29.