CYCLOPENTANE-1,1-DIYLDIMETHANOL

Base Information

• Chemical Name: CYCLOPENTANE-1,1-DIYLDIMETHANOL
• CAS No.: 5763-53-1
• Molecular Formula: C7H14O2
• Molecular Weight: 130.187
• Hs Code.: 2906199090
• Mol file: 5763-53-1.mol

Synonyms:1,1-Bis(hydroxymethyl)cyclopentane;Cyclopentylidenedimethanol;NSC 49657;

Chemical Property of CYCLOPENTANE-1,1-DIYLDIMETHANOL

Chemical Property:

• Vapor Pressure: 0.00213mmHg at 25°C
• Refractive Index: 1.481
• Boiling Point: 257.7 °C at 760 mmHg
• Flash Point: 124.4 °C
• PSA: 40.46000
• Density: 1.047 g/cm³
• LogP: 0.53140

Purity/Quality:

97% purity ^*data from raw suppliers

1,1-Bis(hydroxymethyl)cyclopentane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CYCLOPENTANE-1,1-DIYLDIMETHANOL

There total 7 articles about CYCLOPENTANE-1,1-DIYLDIMETHANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2,2'-(cyclopentane-1,1-diylbis(methylene))bis(oxy)bis(tetrahydro-2H-pyran) → 1,1-bis-(hydroxymethyl)cyclopentane (5763-53-1)

Guidance literature:

With cerium (IV) sulfate tetrahydrate; In methanol; at 130 ℃; for 0.333333h; Temperature; Microwave irradiation;

DOI:10.1016/j.tetlet.2013.10.117

Reference yield: 85.0%

cyclopentane-1,1-dicarboxylic acid diethyl ester (4167-77-5) → 1,1-bis-(hydroxymethyl)cyclopentane (5763-53-1)

Guidance literature:

With lithium aluminium tetrahydride;

DOI:10.1021/ja00256a040

Reference yield: 80.0%

(cyclopentane-1,1-diylbis(methylene))bis(oxy)bis(tert-butyldimethylsilane) (1449746-41-1) → 1,1-bis-(hydroxymethyl)cyclopentane (5763-53-1)

Guidance literature:

With copper(ll) sulfate pentahydrate; In methanol; at 100 ℃; for 0.25h; Microwave irradiation;

DOI:10.1016/j.tetlet.2013.07.074

upstream raw materials:

formaldehyd

cyclopentanealdehyde

cyclopentane-1,1-dicarboxylic acid diethyl ester

(cyclopentane-1,1-diylbis(methylene))bis(oxy)bis(tert-butyldimethylsilane)

Downstream raw materials:

2,3-diethyl(2R,3R)-1,4-dioxaspiro[4.4]nonane-2,3-dicarboxylate

1-methyl-1-cyclopentanecarbaldehyde

2-Methylcyclohexanone

cyclohexanecarbaldehyde

Refernces

• 1、 -. "GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE". Paragraph 001540; 001541; 00154; 001550; 0015518; 001552. . Retrieved 2019/07/17.
• 2、 Gonzalez-Calderon, Davir,Benitez-Puebla, Luis J.,Gonzalez-Gonzalez, Carlos A.,Garcia-Eleno, Marco A.,Fuentes-Benitez, Aydee,Cuevas-Yanez, Erick,Corona-Becerril, David,Gonzalez-Romero, Carlos. "Aluminium chloride hexahydrate (AlCl3.6H2o): An efficient, facile, mild, and highly chemoselective catalytic deprotection of tert-butyldimethylsilyl (tbs) ethers". . p. 1258 - 1265. Retrieved 2014/04/17.