6-Methylquinolin-5-amine

Base Information

• Chemical Name: 6-Methylquinolin-5-amine
• CAS No.: 50358-35-5
• Molecular Formula: C₁₀H₁₀N₂
• Molecular Weight: 158.203
• Hs Code.: 2933499090
• European Community (EC) Number: 624-463-9
• DSSTox Substance ID: DTXSID10388563
• Nikkaji Number: J89.546F
• Wikidata: Q82183616
• ChEMBL ID: CHEMBL1569132
• Mol file: 50358-35-5.mol

Synonyms:6-methylquinolin-5-amine;50358-35-5;6-Methyl-quinolin-5-ylamine;5-Amino-6-methylquinoline;6-Methyl-5-quinolinamine;MFCD00094194;6-Methyl-5-aminoquinoline;6-Methylquinolin-5-ylamine;5-Quinolinamine, 6-methyl-;MLS000718961;SCHEMBL3343150;6-methyl-(quinolin-5-yl)amine;CHEMBL1569132;DTXSID10388563;KQIDQFHIEFDWPM-UHFFFAOYSA-N;5-Amino-6-methylquinoline, 97%;HMS2727A10;BBL034722;STL255754;AKOS000270347;SB67500;NCGC00244976-01;SMR000291229;SY238430;BB 0221207;CS-0370440;FT-0677703;5P-087;EN300-103236;F52640;A871585;J-518931

Chemical Property of 6-Methylquinolin-5-amine

Chemical Property:

• Appearance/Colour: WHITE TO TAN SOLID, POWDER, CRYSTALS,CRYSTALLINE POWDER, AND/OR WITH CHUNKS
• Vapor Pressure: 0.00022mmHg at 25°C
• Melting Point: 133-137 °C
• Refractive Index: 1.681
• Boiling Point: 326.2 °C at 760 mmHg
• PKA: 5.78±0.15(Predicted)
• Flash Point: 177.2 °C
• PSA: 38.91000
• Density: 1.169 g/cm³
• LogP: 2.70660
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 158.084398327
• Heavy Atom Count: 12
• Complexity: 158

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-methyl-5-quinolinamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,Xn
• Hazard Codes: Xi,Xn
• Statements: 22-41
• Safety Statements: 26

MSDS Files:

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC1=C(C2=C(C=C1)N=CC=C2)N
• Uses: Useful aminoquinoline for further quinoline chemistry modifications.

Technology Process of 6-Methylquinolin-5-amine

There total 4 articles about 6-Methylquinolin-5-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.9%

6-methyl-5-nitroquinoline (23141-61-9) → 5-amino-6-methylquinoline (50358-35-5)

Guidance literature:

With hydrogen; In tetrahydrofuran; at 60 ℃; under 15001.5 Torr; Flow reactor;

DOI:10.1021/acs.oprd.1c00164

Reference yield:

6-methylquinoline (91-62-3) → 5-amino-6-methylquinoline (50358-35-5)

Guidance literature:

Multi-step reaction with 2 steps

1: HNO₃+H₂SO₄

2: iron powder; acetic acid

With sulfuric acid; nitric acid; iron; acetic acid;

Reference yield:

6-methyl-5-nitroquinoline (23141-61-9) → 5-amino-6-methylquinoline (50358-35-5)

Guidance literature:

bei der elektrolytischen Reduktion;

upstream raw materials:

6-methyl-5-nitroquinoline

acetic acid

6-methylquinoline

Downstream raw materials:

6-methyl-quinolin-5-ol

5-chloro-6-methyl-quinoline

Refernces

• 1、 Portada, Tomislav,Margeti?, Davor,?trukil, Vjekoslav. "Mechanochemical catalytic transfer hydrogenation of aromatic nitro derivatives". supporting information. . Retrieved 2018/12/11.