Benzeneethanesulfonic acid, a-hydroxy-b-methyl-4-(2-methylpropyl)-, monosodium salt

Base Information

• Chemical Name: Benzeneethanesulfonic acid, a-hydroxy-b-methyl-4-(2-methylpropyl)-, monosodium salt
• CAS No.: 62741-02-0
• Molecular Formula: C13H20O4S.Na
• Molecular Weight: 294.347
• Mol file: 62741-02-0.mol

Synonyms:

Chemical Property of Benzeneethanesulfonic acid, a-hydroxy-b-methyl-4-(2-methylpropyl)-, monosodium salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzeneethanesulfonic acid, a-hydroxy-b-methyl-4-(2-methylpropyl)-, monosodium salt

There total 1 articles about Benzeneethanesulfonic acid, a-hydroxy-b-methyl-4-(2-methylpropyl)-, monosodium salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-isobutylphenyl)propionaldehyde (51407-46-6) → Sodium; 1-hydroxy-2-(4-isobutyl-phenyl)-propane-1-sulfonate (62741-02-0)

Guidance literature:

With sodium hydrogensulfite; In methanol; water;

DOI:10.1016/S0040-4039(00)84893-5

Reference yield:

sodium methylate (124-41-4) + Sodium; 1-hydroxy-2-(4-isobutyl-phenyl)-propane-1-sulfonate (62741-02-0) → (+/-)-ibuprofen methyl ester (61566-34-5)

Guidance literature:

In methanol;

DOI:10.1016/S0040-4039(00)84893-5

Reference yield:

Sodium; 1-hydroxy-2-(4-isobutyl-phenyl)-propane-1-sulfonate (62741-02-0) → ibuprofen (15687-27-1,58560-75-1)

Guidance literature:

Multi-step reaction with 2 steps

1: DMSO, Ac₂O / 24 h / Ambient temperature

2: K₂CO₃ / H₂O

With acetic anhydride; potassium carbonate; dimethyl sulfoxide; In water;

DOI:10.1016/S0040-4039(00)84893-5

upstream raw materials:

2-(4-isobutylphenyl)propionaldehyde

Downstream raw materials:

(+/-)-ibuprofen methyl ester

ibuprofen

Refernces