CYCLOHEPTYLACETIC ACID

Base Information

• Chemical Name: CYCLOHEPTYLACETIC ACID
• CAS No.: 4401-20-1
• Molecular Formula: C9H16O2
• Molecular Weight: 156.225
• Hs Code.: 2916209090
• Mol file: 4401-20-1.mol

Synonyms:Cycloheptylaceticacid;NSC 18970;

Chemical Property of CYCLOHEPTYLACETIC ACID

Chemical Property:

• Vapor Pressure: 0.00215mmHg at 25°C
• Melting Point: 14-15 °C
• Refractive Index: 1.4725
• Boiling Point: 268.7 °C at 760 mmHg
• Flash Point: 133.2 °C
• PSA: 37.30000
• Density: 0.998 g/cm³
• LogP: 2.43150

Purity/Quality:

99% ^*data from raw suppliers

2-CycloheptylaceticAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:Irritating to eyes, respiratory system and skin.
• Hazard Codes: Xn
• Statements: 36/37/38-51-41-37/38-22
• Safety Statements: 26-36/37/39-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CYCLOHEPTYLACETIC ACID

There total 11 articles about CYCLOHEPTYLACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

diazoacetylcycloheptane (193222-78-5) → 2-cycloheptylacetic acid (4401-20-1) + cycloheptanoic acid (1460-16-8) + Bicyclo<4.2.1>nonan-8-on (66050-43-9)

Guidance literature:

With dirhodium tetraacetate; In dichloromethane; for 5h; Yields of byproduct given;

DOI:10.1016/S0040-4020(97)00507-3

Reference yield: 36.0%

diazoacetylcycloheptane (193222-78-5) → 2-cycloheptylacetic acid (4401-20-1) + Bicyclo<4.2.1>nonan-8-on (66050-43-9) + trans-bicyclo<5.2.0>nonan-8-one + 3-Cycloheptyl-4-[1-cycloheptyl-meth-(Z)-ylidene]-oxetan-2-one

Guidance literature:

With tetrakis(trifluoroacetato)rhodium(II); In dichloromethane; for 5h; Further byproducts given. Yields of byproduct given;

DOI:10.1016/S0040-4020(97)00507-3

Reference yield:

→ 2-cycloheptylacetic acid (4401-20-1)

Guidance literature:

With potassium hydroxide; sulfuric acid; Erhitzen des Reaktionsprodukts auf 220grad;

DOI:10.1021/jo01118a033

upstream raw materials:

cycloheptylideneacetic acid

(cyclohepten-1-yl)acetic acid

cycloheptyl-malonic acid

diazoacetylcycloheptane

Downstream raw materials:

4-cycloheptyl-3-oxo-2-(triphenyl-λ⁵phosphatylidene)butyric acid ethyl ester

2-cycloheptylacetaldehyde

Refernces

• 1、 Protiva, Miroslav,Valenta, Vladimir,Kopicova, Zdenka,Lukac, Juraj,Holubek, Jiri,Krejci, Ivan. "POTENTIAL CEREBRAL STIMULANTS: ESTERS OF 2-DIMETHYLAMINOETHANOL WITH SOME LIPOPHILIC CARBOXYLIC ACIDS". . p. 1278 - 1289. Retrieved 2007/10/02.